{"id":"hipec","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Infection/peritonitis"},{"rate":null,"effect":"Bowel perforation"},{"rate":null,"effect":"Hematologic toxicity"},{"rate":null,"effect":"Renal toxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HIPEC combines regional chemotherapy delivery with hyperthermia (heat) to enhance drug penetration and cytotoxicity in peritoneal tumors while minimizing systemic exposure. The heated chemotherapy solution is perfused throughout the peritoneal cavity during cytoreductive surgery, allowing direct contact with cancer cells and peritoneal surfaces. The combination of heat and chemotherapy is intended to improve local control and survival in patients with peritoneal carcinomatosis.","oneSentence":"HIPEC is a hyperthermic intraperitoneal chemotherapy delivery system that circulates heated chemotherapy drugs directly into the abdominal cavity during surgery to treat peritoneal cancers.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:36.418Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Peritoneal carcinomatosis from colorectal cancer"},{"name":"Peritoneal carcinomatosis from ovarian cancer"},{"name":"Peritoneal mesothelioma"}]},"trialDetails":[{"nctId":"NCT04847063","phase":"PHASE1","title":"Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2021-10-19","conditions":"Peritoneal Mesothelioma, Peritoneal Carcinomatosis, Ovarian Cancer","enrollment":60},{"nctId":"NCT05001880","phase":"PHASE2","title":"Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2022-03-22","conditions":"Peritoneal Malignant Mesothelioma","enrollment":66},{"nctId":"NCT07493876","phase":"NA","title":"Enhanced Recovery After Surgery (ERAS) in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery With or Without HIPEC","status":"RECRUITING","sponsor":"Fondazione del Piemonte per l'Oncologia","startDate":"2025-01-23","conditions":"Peritoneal Carcinomatosis","enrollment":300},{"nctId":"NCT07493421","phase":"NA","title":"To Evaluate the Feasibility and Safety of Combining Surgery (Pancreatectomy and Cytoreduction) With HIPEC for Treating Pancreatic Cancer With Peritoneal 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Ovarian","enrollment":140},{"nctId":"NCT05415709","phase":"EARLY_PHASE1","title":"Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2022-06-13","conditions":"Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma","enrollment":45},{"nctId":"NCT01815359","phase":"PHASE2","title":"ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2013-03","conditions":"Appendix Cancer, Colorectal 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Health","startDate":"2021-04-16","conditions":"Gastric Adenocarcinoma","enrollment":30},{"nctId":"NCT05449366","phase":"PHASE1, PHASE2","title":"Intraperitoneal Paclitaxel for Patients With Primary Malignant Peritoneal Mesothelioma","status":"COMPLETED","sponsor":"Erasmus Medical Center","startDate":"2022-02-01","conditions":"Peritoneal Malignant Mesothelioma","enrollment":7},{"nctId":"NCT03732781","phase":"PHASE1, PHASE2","title":"Study of Radspherin® in Colorectal Carcinoma Subjects With Peritoneal Carcinomatosis Treated With HIPEC","status":"COMPLETED","sponsor":"Oncoinvent Solutions AS","startDate":"2020-05-27","conditions":"Peritoneal Carcinoma, Colorectal Carcinoma","enrollment":47},{"nctId":"NCT01767675","phase":"PHASE2","title":"Outcomes After Secondary Cytoreductive Surgery With or Without Carboplatin Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Followed by Systemic Combination Chemotherapy for Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal 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Center","startDate":"2023-09-21","conditions":"Malignant Peritoneal Mesothelioma, Peritoneal Mesothelioma, Mesothelioma","enrollment":64},{"nctId":"NCT05406674","phase":"PHASE2","title":"Body Surface Area-based vs Concentration-based Dosing of Cisplatin for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Women With Advanced Ovarian Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Netherlands Cancer Institute","startDate":"2022-06-15","conditions":"FIGO Stage III Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Carcinoma","enrollment":40},{"nctId":"NCT03348150","phase":"PHASE3","title":"Gastrectomy + Cytoreductive Surgery + HIPEC for Gastric Cancer With Peritoneal Dissemination.","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Netherlands Cancer Institute","startDate":"2017-10-01","conditions":"Stomach Neoplasm, Peritoneal Carcinomatosis","enrollment":102},{"nctId":"NCT06427252","phase":"PHASE2","title":"The Efficacy and Safety of HIPEC Combined With PD-1 and SOX 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Chemotherapy","status":"RECRUITING","sponsor":"Uppsala University","startDate":"2021-05-01","conditions":"Colorectal Cancer, Peritoneal Metastases","enrollment":213},{"nctId":"NCT05652348","phase":"","title":"Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer","status":"RECRUITING","sponsor":"Technische Universität Dresden","startDate":"2022-12-08","conditions":"Gastric Cancer, Colon Cancer, Peritoneal Carcinomatosis","enrollment":48},{"nctId":"NCT02672098","phase":"PHASE1","title":"Hyperthermic Intraperitoneal Chemotherapy for Recurrent Ovarian Cancer","status":"COMPLETED","sponsor":"Loma Linda University","startDate":"2016-07-14","conditions":"Ovarian Cancer","enrollment":3},{"nctId":"NCT06903039","phase":"","title":"NeoRes Study - Preoperative Chemotherapy in Colorectal Peritoneal Disease Prior to Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)","status":"COMPLETED","sponsor":"Uppsala University","startDate":"2019-03-21","conditions":"Colorectal Cancer Metastatic, Peritoneal Metastases From Colorectal Cancer","enrollment":185},{"nctId":"NCT06946901","phase":"PHASE2","title":"The Safety and Effectiveness of Hyperthermic Intraperitoneal Chemotherapy Combined With Intravenous Chemotherapy for Peritoneal Metastatic Pancreatic Cancer, a Phase II Clinical Trial","status":"RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2025-04-03","conditions":"Hyperthermic Intraperitoneal Chemotherapy, Peritoneal Metastatic Pancreatic Cancer","enrollment":90},{"nctId":"NCT01376752","phase":"PHASE3","title":"Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) in Relapse Ovarian Cancer Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"UNICANCER","startDate":"2011-04-26","conditions":"Ovarian Epithelial Cancer Recurrent","enrollment":415},{"nctId":"NCT06922227","phase":"","title":"HIPEC Surgery and Hemodynamics","status":"NOT_YET_RECRUITING","sponsor":"Miray Gözde Özdemir","startDate":"2025-04-01","conditions":"Hemodynamics, Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy (HIPEC)","enrollment":15},{"nctId":"NCT06685887","phase":"PHASE2","title":"A Clinical Study Evaluating the Efficacy of Systemic Chemotherapy and Immune Checkpoint Inhibitors Combined With Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer Patients With Peritoneal Metastasis","status":"RECRUITING","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2025-02-15","conditions":"Gastric Cancer","enrollment":34},{"nctId":"NCT06914687","phase":"PHASE2","title":"Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma","status":"NOT_YET_RECRUITING","sponsor":"Fudan University","startDate":"2025-03-30","conditions":"Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal 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