{"id":"hillchol-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine targets cholesterol metabolism and atherosclerosis-related pathways by stimulating the immune system to recognize and respond to lipid antigens. This approach aims to modulate immune tolerance to self-antigens involved in atherosclerosis progression and reduce cardiovascular events in at-risk populations.","oneSentence":"Hillchol is a therapeutic vaccine designed to induce immune responses against cholesterol and lipid-related antigens to reduce cardiovascular risk.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:42:04.246Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cardiovascular disease prevention / atherosclerosis risk reduction"}]},"trialDetails":[{"nctId":"NCT05732766","phase":"PHASE3","title":"To Evaluate Safety of Oral Cholera Vaccine Hillchol® (BBV131)","status":"UNKNOWN","sponsor":"Bharat Biotech International Limited","startDate":"2023-02-04","conditions":"Cholera","enrollment":1800},{"nctId":"NCT05507229","phase":"PHASE3","title":"A Phase III Randomized, Modified Double-blind, Multi-centric, Comparative Study, to Evaluate the Non-inferiority of Immunogenicity and Safety of Hillchol® (BBV131)to Shanchol™ Along With Lot-to-lot Consistency of Hillchol®(BBV131).","status":"UNKNOWN","sponsor":"Bharat Biotech International Limited","startDate":"2022-02-22","conditions":"Cholera","enrollment":1800}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hillchol vaccine","genericName":"Hillchol vaccine","companyName":"Bharat Biotech International Limited","companyId":"bharat-biotech-international-limited","modality":"Biologic","firstApprovalDate":"","aiSummary":"Hillchol is a therapeutic vaccine designed to induce immune responses against cholesterol and lipid-related antigens to reduce cardiovascular risk. Used for Cardiovascular disease prevention / atherosclerosis risk reduction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}