{"id":"higher-dose-sodium-bicarbonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Metabolic alkalosis"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Hypertension"}]},"_chembl":{"chemblId":"CHEMBL1353","moleculeType":"Small molecule","molecularWeight":"84.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium bicarbonate is a buffer that increases systemic and urinary alkalinity. At higher doses, it is hypothesized to reduce tubular toxicity, decrease crystal formation in renal tubules, and mitigate ischemic injury in the kidneys. This mechanism is being investigated for renoprotection in various acute and chronic kidney disease settings.","oneSentence":"Higher dose sodium bicarbonate raises blood and urine pH to create an alkaline environment that may reduce kidney injury and improve renal function.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:41:59.958Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute kidney injury prevention or treatment (Phase 3 investigational)"},{"name":"Chronic kidney disease progression (Phase 3 investigational)"}]},"trialDetails":[{"nctId":"NCT04081714","phase":"","title":"Intermediate Expanded Access Protocol CNMAu8.EAP03","status":"TEMPORARILY_NOT_AVAILABLE","sponsor":"Clene Nanomedicine","startDate":"","conditions":"Multiple Sclerosis","enrollment":""},{"nctId":"NCT05411991","phase":"PHASE4","title":"Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment","status":"COMPLETED","sponsor":"Vrije Universiteit Brussel","startDate":"2022-06-12","conditions":"Acute Heart Failure, Diuretics Drug Reactions","enrollment":107},{"nctId":"NCT06983509","phase":"","title":"Registry of Pre-mixed Solutions in Critically Ill Patients on the Continuous Renal Replacement Therapy","status":"RECRUITING","sponsor":"Vantive Health LLC","startDate":"2024-09-23","conditions":"Renal Insufficiency","enrollment":220},{"nctId":"NCT04984226","phase":"PHASE2","title":"Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2023-09-08","conditions":"Chronic Kidney Diseases, Metabolic Acidosis, Fatigue","enrollment":80},{"nctId":"NCT06817681","phase":"NA","title":"Exercise-Induced Lactate and Cognitive Function (ExLBC)","status":"NOT_YET_RECRUITING","sponsor":"McMaster University","startDate":"2025-02-10","conditions":"Cognition, Sodium Bicarbonate, Lactate","enrollment":32},{"nctId":"NCT04822246","phase":"NA","title":"Root Caries Excavation with Air Water/powder Prophylaxis Device for ART Restorations","status":"ACTIVE_NOT_RECRUITING","sponsor":"Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS","startDate":"2021-09-30","conditions":"Dental Caries Extending Into Dentin, Root Caries","enrollment":62},{"nctId":"NCT06032884","phase":"NA","title":"IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-10-28","conditions":"Acute Kidney Injury","enrollment":1000},{"nctId":"NCT03301558","phase":"PHASE2","title":"The Effect of Sodium Bicarbonate (Nephrotrans®) on Calcification Propensity of Serum in Kidney Transplant Recipients","status":"WITHDRAWN","sponsor":"Prim. 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Response Syndrome, Oliguria, Renal Impairment","enrollment":70},{"nctId":"NCT00878956","phase":"PHASE2","title":"Bicarbonate in Cardiac Surgery","status":"TERMINATED","sponsor":"Austin Health","startDate":"2009-04","conditions":"Acute Kidney Injury","enrollment":427},{"nctId":"NCT01612013","phase":"NA","title":"Intravenous High Dose NAC and Sodium Bicarbonate for the Prevention of Contrast-induced Acute Injury","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2005-05","conditions":"Acute Renal Failure","enrollment":500},{"nctId":"NCT00709410","phase":"NA","title":"Mass Oral Cholera Vaccination in Zanzibar","status":"COMPLETED","sponsor":"International Vaccine Institute","startDate":"2009-01","conditions":"Cholera, Diarrhea","enrollment":51151},{"nctId":"NCT00570817","phase":"NA","title":"Prevention of Methotrexate Induced Nephrotoxicity and Prolonged Drug Elimination Time With 12 Hours Prehydration","status":"COMPLETED","sponsor":"University of 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multiple sclerosis, systemic inflammatory response syndrome, and oliguria, according to ClinicalTrials.gov. Sodium bicarbonate is a small molecule with the chemical name carbonic acid monosodium salt, classified as a small molecule modality, as per ChEMBL.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}