{"id":"higher-dose-recfsh","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal pain/bloating"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL664","moleculeType":"Small molecule","molecularWeight":"176.22"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"recFSH is a recombinant version of the naturally occurring follicle-stimulating hormone that binds to FSH receptors on ovarian granulosa cells, promoting follicular growth and estrogen production. Higher doses are used in controlled ovarian hyperstimulation protocols to recruit and mature multiple oocytes simultaneously for in vitro fertilization (IVF) and other assisted reproductive technologies.","oneSentence":"Recombinant follicle-stimulating hormone (recFSH) at higher doses stimulates the ovaries to produce multiple mature eggs for assisted reproductive procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:27.925Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Controlled ovarian hyperstimulation in assisted reproductive technology (ART) / in vitro fertilization (IVF)"},{"name":"Anovulation and infertility in women"}]},"trialDetails":[{"nctId":"NCT07121751","phase":"PHASE4","title":"Optimal Stimulation of Hypo-responders Undergoing in Vitro Fertilization (IVF)","status":"NOT_YET_RECRUITING","sponsor":"Dunamenti REK Istenhegyi IVF Center","startDate":"2025-09-01","conditions":"Hypo-responder, Infertility (IVF Patients), OVARIAN STIMULATION","enrollment":150},{"nctId":"NCT05330130","phase":"PHASE1","title":"Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells","status":"COMPLETED","sponsor":"ART Fertility Clinics LLC","startDate":"2023-07-05","conditions":"Ovarian Function Insufficiency, Fertility Issues, Infertility,Female","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"higher dose recFSH","genericName":"higher dose recFSH","companyName":"Dunamenti REK Istenhegyi IVF Center","companyId":"dunamenti-rek-istenhegyi-ivf-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Recombinant follicle-stimulating hormone (recFSH) at higher doses stimulates the ovaries to produce multiple mature eggs for assisted reproductive procedures. Used for Controlled ovarian hyperstimulation in assisted reproductive technology (ART) / in vitro fertilization (IVF), Anovulation and infertility in women.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}