{"id":"high-hyal-plus-inj","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Transient local inflammation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL780","moleculeType":"Small molecule","molecularWeight":"393.35"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hyaluronic acid is a naturally occurring polysaccharide that acts as a lubricant and shock absorber in joints and connective tissues. The 'Plus' formulation likely indicates an enhanced or cross-linked version designed to improve retention time and efficacy. This mechanism supports tissue hydration, reduces friction, and may promote healing in damaged or degenerative tissues.","oneSentence":"High hyal Plus is a hyaluronic acid-based injectable that provides viscoelastic supplementation and tissue hydration for joint or dermatological applications.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:41:51.664Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis (likely knee or other joints)"},{"name":"Dermatological applications (skin hydration/rejuvenation)"}]},"trialDetails":[{"nctId":"NCT06798727","phase":"PHASE2","title":"Evaluation Safety and Explore Efficacy Long-term Follow-up Study on Subjects Receiving SMUP-IA-01 or Active Control","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medipost Co Ltd.","startDate":"2023-03-20","conditions":"Knee Osteoarthritis","enrollment":84},{"nctId":"NCT02893098","phase":"PHASE3","title":"A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Huons Co., Ltd.","startDate":"2016-08","conditions":"Osteoarthritis of Knee","enrollment":232}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"High hyal Plus inj.","genericName":"High hyal Plus inj.","companyName":"Huons Co., Ltd.","companyId":"huons-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"High Hyal Plus injection is a small molecule used to treat knee osteoarthritis and osteoarthritis of the knee. It is administered as part of a clinical study to evaluate its safety and efficacy in patients with these conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}