{"id":"high-flow-medical-oxygen-insufflation","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation or drying"},{"rate":null,"effect":"Discomfort from high-flow delivery"},{"rate":null,"effect":"Oxygen toxicity (with prolonged high-concentration use)"}]},"_chembl":{"chemblId":"CHEMBL1234886","moleculeType":"Small molecule","molecularWeight":"32.00"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a medical gas delivery system that provides oxygen at higher flow rates than standard supplemental oxygen, increasing the fraction of inspired oxygen (FiO2) and improving arterial oxygen saturation. It is used in acute respiratory distress and hypoxemic conditions to enhance oxygen availability to tissues and reduce the work of breathing.","oneSentence":"High-flow medical oxygen insufflation delivers oxygen at elevated flow rates to improve tissue oxygenation and support respiratory function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:19.342Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypoxemic respiratory failure"},{"name":"Severe hypoxemia requiring high-flow oxygen support"}]},"trialDetails":[{"nctId":"NCT07439822","phase":"PHASE4","title":"Usefulness of High-flow Oxygen Therapy of Patients at Risk of Hypoxemia Undergoing Digestive Endoscopy Under Deep Sedation","status":"ENROLLING_BY_INVITATION","sponsor":"Outcomes'10","startDate":"2026-03","conditions":"Hypoxemia During Surgery","enrollment":326}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"High-flow medical oxygen insufflation","genericName":"High-flow medical oxygen insufflation","companyName":"Outcomes'10","companyId":"outcomes-10","modality":"Small molecule","firstApprovalDate":"","aiSummary":"High-flow medical oxygen insufflation delivers oxygen at elevated flow rates to improve tissue oxygenation and support respiratory function. Used for Acute hypoxemic respiratory failure, Severe hypoxemia requiring high-flow oxygen support.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}