{"id":"high-dose-immunoablative-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection (bacterial, viral, fungal)"},{"rate":null,"effect":"Mucositis"},{"rate":null,"effect":"Hematologic toxicity (neutropenia, thrombocytopenia)"},{"rate":null,"effect":"Organ toxicity (cardiac, renal, hepatic)"},{"rate":null,"effect":"Graft-versus-host disease (GVHD)"},{"rate":null,"effect":"Secondary malignancy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This approach aims to 'reset' the immune system by destroying autoreactive T and B cells responsible for autoimmune disease, then restoring immune function with reinfused patient stem cells that have been selected or manipulated to prevent disease recurrence. The goal is to achieve long-term remission or cure of severe autoimmune conditions by eliminating the pathogenic immune clone while preserving protective immunity.","oneSentence":"High-dose immunoablative therapy uses intensive chemotherapy and/or radiation to eliminate the patient's immune system, followed by autologous hematopoietic stem cell transplantation to reconstitute a new, disease-tolerant immune system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:23.924Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe systemic sclerosis (scleroderma)"},{"name":"Severe refractory systemic lupus erythematosus"},{"name":"Severe refractory rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT04047628","phase":"PHASE3","title":"Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2019-12-19","conditions":"Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis","enrollment":156},{"nctId":"NCT05832515","phase":"PHASE1","title":"AHSCT With Fludarabine and Cyclophosphamide Based Conditioning Regimes in Patients With Multiple Sclerosis","status":"RECRUITING","sponsor":"St. Petersburg State Pavlov Medical University","startDate":"2020-10-01","conditions":"Multiple Sclerosis","enrollment":200},{"nctId":"NCT01639573","phase":"","title":"Campath-1h Phase I/II Pilot Trial as Immunoablative Therapy for Refractory Systemic Sclerosis","status":"WITHDRAWN","sponsor":"Children's Hospital Los Angeles","startDate":"2011-04","conditions":"Scleroderma","enrollment":""},{"nctId":"NCT00005778","phase":"PHASE3","title":"High-Dose Intravenous (IV) Cyclophosphamide Versus Monthly IV Cyclophosphamide","status":"COMPLETED","sponsor":"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","startDate":"2000-01","conditions":"Lupus Erythematosus, Systemic","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"High-dose immunoablative therapy","genericName":"High-dose immunoablative therapy","companyName":"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","companyId":"national-institute-of-arthritis-and-musculoskeletal-and-skin-diseases-niams","modality":"Small molecule","firstApprovalDate":"","aiSummary":"High-dose immunoablative therapy uses intensive chemotherapy and/or radiation to eliminate the patient's immune system, followed by autologous hematopoietic stem cell transplantation to reconstitute a new, disease-tolerant immune system. Used for Severe systemic sclerosis (scleroderma), Severe refractory systemic lupus erythematosus, Severe refractory rheumatoid arthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}