{"id":"high-dose-ifn-a2b","safety":{"commonSideEffects":[{"rate":"70-90","effect":"Flu-like symptoms (fever, chills, fatigue)"},{"rate":"10-30","effect":"Hepatotoxicity"},{"rate":"20-40","effect":"Myelosuppression"},{"rate":"10-20","effect":"Depression/neuropsychiatric effects"},{"rate":"5-15","effect":"Autoimmune phenomena"}]},"_chembl":{"chemblId":"CHEMBL4280177","moleculeType":"Small molecule","molecularWeight":"534.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IFN-α2b is a cytokine that binds to interferon-alpha receptors on immune cells and tumor cells, triggering JAK-STAT signaling pathways. This leads to upregulation of MHC molecules, enhanced natural killer cell and T-cell activation, increased production of pro-inflammatory cytokines, and direct anti-proliferative effects on malignant cells. High-dose regimens are designed to maximize systemic immune activation for cancer treatment.","oneSentence":"High-dose interferon-alpha-2b activates the innate and adaptive immune system to enhance anti-tumor immunity and inhibit tumor cell proliferation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:14.550Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Melanoma (adjuvant or metastatic disease)"},{"name":"Other solid tumors under investigation"}]},"trialDetails":[{"nctId":"NCT01274338","phase":"PHASE3","title":"Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2011-05-25","conditions":"Melanoma of Unknown Primary, Recurrent Melanoma, Stage IIIB Cutaneous Melanoma AJCC v7","enrollment":1673},{"nctId":"NCT00134030","phase":"PHASE3","title":"Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma","status":"COMPLETED","sponsor":"Children's Oncology Group","startDate":"2005-11-14","conditions":"Localized Osteosarcoma, Metastatic Osteosarcoma","enrollment":1334},{"nctId":"NCT04277663","phase":"PHASE3","title":"The Study of IBI310 in Combination With IBI308 Compared to High-Dose Interferon In Patients With Acral Melanoma That Has Been Removed by Surgery","status":"TERMINATED","sponsor":"Innovent Biologics (Suzhou) Co. Ltd.","startDate":"2020-04-17","conditions":"Acral Melanoma That Has Been Removed by Surgery","enrollment":136},{"nctId":"NCT03178123","phase":"PHASE2","title":"The Study of JS001 Compared to High-Dose Interferon In Patients With Mucosal Melanoma That Has Been Removed by Surgery","status":"UNKNOWN","sponsor":"Shanghai Junshi Bioscience Co., Ltd.","startDate":"2017-05-31","conditions":"Mucosal Melanoma","enrollment":220},{"nctId":"NCT03435302","phase":"PHASE3","title":"HDI Versus Chemotherapy as Systemic Adjuvant Therapy for Resected Mucosal Melanoma","status":"UNKNOWN","sponsor":"Peking University Cancer Hospital & Institute","startDate":"2014-02","conditions":"Melanoma","enrollment":204}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Intron"],"phase":"phase_3","status":"active","brandName":"High-Dose IFN-a2b","genericName":"High-Dose IFN-a2b","companyName":"Peking University Cancer Hospital & Institute","companyId":"peking-university-cancer-hospital-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"High-dose interferon-alpha-2b activates the innate and adaptive immune system to enhance anti-tumor immunity and inhibit tumor cell proliferation. Used for Melanoma (adjuvant or metastatic disease), Other solid tumors under investigation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}