{"id":"high-dose-epinephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myocardial ischemia"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epinephrine binds to alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors throughout the body. At high doses, it predominantly activates alpha-adrenergic receptors, causing vasoconstriction and increased systemic vascular resistance, while also enhancing myocardial contractility and heart rate via beta-1 receptor activation. 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