{"id":"high-dose-bisoprolol","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Fatigue"},{"rate":"5-15","effect":"Dizziness"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Hypotension"},{"rate":"2-5","effect":"Dyspnea"},{"rate":"5-10","effect":"Headache"},{"rate":"2-5","effect":"Insomnia"},{"rate":"2-5","effect":"Sexual dysfunction"}]},"_chembl":{"chemblId":"CHEMBL645","moleculeType":"Small molecule","molecularWeight":"325.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bisoprolol selectively blocks beta-1 adrenergic receptors on the heart, decreasing sympathetic nervous system activity. This results in reduced heart rate, decreased force of cardiac contraction, and lower blood pressure. At high doses, it may also have modest beta-2 blocking effects, though selectivity for beta-1 is maintained.","oneSentence":"High-dose bisoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate and cardiac contractility to lower blood pressure and improve cardiac function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:43.795Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Heart failure with reduced ejection fraction"},{"name":"Post-myocardial infarction"},{"name":"Atrial fibrillation rate control"}]},"trialDetails":[{"nctId":"NCT03646357","phase":"PHASE4","title":"BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function","status":"ACTIVE_NOT_RECRUITING","sponsor":"Oslo University Hospital","startDate":"2018-10-01","conditions":"Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction","enrollment":2895},{"nctId":"NCT05122780","phase":"PHASE4","title":"Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2021-07-01","conditions":"Myocardial Infarction With Non-Obstructive Coronary Arteries","enrollment":120},{"nctId":"NCT03011775","phase":"PHASE4","title":"Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease","status":"COMPLETED","sponsor":"Ukrainian Medical Stomatological Academy","startDate":"2012-11","conditions":"Adverse Effect, Atherosclerosis, Coronary, Insulin Resistance Syndrome","enrollment":43},{"nctId":"NCT01074307","phase":"PHASE4","title":"A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2009-10","conditions":"Heart Failure, Congestive","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Concor"],"phase":"marketed","status":"active","brandName":"High Dose Bisoprolol","genericName":"High Dose Bisoprolol","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"High-dose bisoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate and cardiac contractility to lower blood pressure and improve cardiac function. Used for Hypertension, Angina pectoris, Heart failure with reduced ejection fraction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}