{"id":"high-bup-nal-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Sweating"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Buprenorphine acts as a partial agonist at the mu-opioid receptor, providing sufficient opioid activity to prevent withdrawal while having a ceiling effect that reduces overdose risk. Naloxone is included as an antagonist to deter intravenous misuse. At higher doses than standard formulations, this combination aims to improve treatment outcomes and reduce illicit opioid use in patients with opioid use disorder.","oneSentence":"A combination of buprenorphine (partial opioid agonist) and naloxone (opioid antagonist) at higher doses to treat opioid use disorder with improved efficacy and safety.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:14.318Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Opioid use disorder"}]},"trialDetails":[{"nctId":"NCT00710385","phase":"PHASE3","title":"Abuse Liability of Suboxone Versus Subutex","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2007-09","conditions":"Opioid-related Disorders","enrollment":19}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Suboxone"],"phase":"phase_3","status":"active","brandName":"High Bup/Nal Dose","genericName":"High Bup/Nal Dose","companyName":"New York State Psychiatric Institute","companyId":"new-york-state-psychiatric-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Buprenorphine, a small molecule, is used to treat opioid-related disorders. It is often administered in combination with naloxone, a medication that counteracts opioid effects, to prevent misuse.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}