{"id":"hib-menac-mixed-with-tritanrix-hepb","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, redness, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability or fussiness"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":{"chemblId":"CHEMBL10933","moleculeType":"Small molecule","molecularWeight":"431.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hib-MenAC provides conjugate vaccines against Haemophilus influenzae type b and meningococcal serogroups A and C, while Tritanrix-HepB is a pentavalent vaccine covering diphtheria, tetanus, acellular pertussis, hepatitis B, and inactivated poliomyelitis. When mixed, the combination elicits humoral and cellular immune responses to prevent these infectious diseases in infants and young children.","oneSentence":"This combination vaccine stimulates immune responses against Haemophilus influenzae type b, Neisseria meningitidis serogroups A and C, diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis through antigen presentation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:13.478Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of Haemophilus influenzae type b infection in infants and children"},{"name":"Prevention of meningococcal disease (serogroups A and C) in infants and children"},{"name":"Prevention of diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis in infants and children"}]},"trialDetails":[{"nctId":"NCT00317135","phase":"PHASE3","title":"Safety Study of a Vaccine Against Meningitis in Infants ( 2,4 & 6 Months Age) After a Birth Dose of Hepatitis B.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2003-12-11","conditions":"Diphtheria, Hepatitis B, Whole Cell Pertussis","enrollment":500},{"nctId":"NCT00317187","phase":"PHASE3","title":"Safety Study of a Vaccine Against Meningitis in Infants (2,4 & 6 Months Age) After a Birth Dose of Hepatitis B.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2004-06-08","conditions":"Hepatitis B, Diphtheria, Whole Cell Pertussis","enrollment":500},{"nctId":"NCT00197275","phase":"PHASE3","title":"Lot-to-lot Consistency of Tritanrix™-HepB/Hib-MenAC & Its Non-inferiority vs Tritanrix™-HepB/Hiberix™ in Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-02","conditions":"Tetanus, Hepatitis B, Haemophilus Influenzae Type b","enrollment":800},{"nctId":"NCT00291967","phase":"PHASE2","title":"Assess Immune Response Following Primary Vaccination With Tritanrix™-HepB Vaccine Mixed With 3 Formulations of Hib-MenAC Vaccine to Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2002-11","conditions":"Diphtheria, Tetanus, Pertussis","enrollment":525}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hib-MenAC mixed with Tritanrix™-HepB","genericName":"Hib-MenAC mixed with Tritanrix™-HepB","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"This combination vaccine stimulates immune responses against Haemophilus influenzae type b, Neisseria meningitidis serogroups A and C, diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis through antigen presentation. Used for Prevention of Haemophilus influenzae type b infection in infants and children, Prevention of meningococcal disease (serogroups A and C) in infants and children, Prevention of diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis in infants and children.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}