{"id":"hi-dose-iv-mgso4","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hypermagnesemia"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium sulfate functions as a non-competitive antagonist at NMDA receptors, reducing excitotoxic calcium influx into neurons. It also stabilizes cell membranes and modulates neurotransmitter release, providing neuroprotection in acute neurological conditions. The high-dose intravenous formulation allows rapid achievement of therapeutic concentrations in the central nervous system.","oneSentence":"High-dose intravenous magnesium sulfate acts as a neuroprotective agent and anticonvulsant by blocking N-methyl-D-aspartate (NMDA) receptors and stabilizing neuronal membranes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:14.173Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuroprotection in acute ischemic stroke"},{"name":"Seizure prophylaxis in eclampsia/preeclampsia"},{"name":"Traumatic brain injury neuroprotection"}]},"trialDetails":[{"nctId":"NCT02455687","phase":"PHASE3","title":"Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2015-06","conditions":"Bronchial Asthma","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hi-dose iv MgSO4","genericName":"Hi-dose iv MgSO4","companyName":"Hamad Medical Corporation","companyId":"hamad-medical-corporation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"High-dose intravenous magnesium sulfate acts as a neuroprotective agent and anticonvulsant by blocking N-methyl-D-aspartate (NMDA) receptors and stabilizing neuronal membranes. Used for Neuroprotection in acute ischemic stroke, Seizure prophylaxis in eclampsia/preeclampsia, Traumatic brain injury neuroprotection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}