{"id":"hgp0816","safety":{"commonSideEffects":[{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HGP0816 works by binding to the androgen receptor and recruiting it for proteasomal degradation, thereby eliminating both the protein and its transcriptional activity. This mechanism differs from traditional androgen receptor antagonists by completely removing the receptor rather than simply blocking its function, potentially overcoming resistance mechanisms seen with conventional anti-androgens.","oneSentence":"HGP0816 is a selective androgen receptor degrader (SARD) that binds to and promotes degradation of the androgen receptor protein.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:06.766Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Castration-resistant prostate cancer (CRPC)"}]},"trialDetails":[{"nctId":"NCT04039724","phase":"PHASE1","title":"Pharmacokinetics of HCP1305 and Co-administration of HCP0605, HGP0816 in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2015-02","conditions":"Healthy","enrollment":61},{"nctId":"NCT02941796","phase":"PHASE1","title":"Pharmacokinetics and Safety of HCP1105 and Co-administration of HGP0918, HGP0816 in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2016-06","conditions":"Hyperlipidemias","enrollment":68},{"nctId":"NCT02941848","phase":"PHASE1","title":"Evaluate the Pharmacokinetics and Safety of HCP1306 and Co-administration of HGP0816, HGP1404 in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2014-11","conditions":"Primary Hypercholesterolemia","enrollment":60},{"nctId":"NCT02899455","phase":"PHASE3","title":"Clinical Efficacy and Safety Evaluation of Co-administered HGP0904, HGP0608 and HGP0816 in Patients With Hypertension and Dyslipidemia","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2014-07","conditions":"Hypertension, Hyperlipidemia","enrollment":146},{"nctId":"NCT02205606","phase":"PHASE3","title":"Efficacy/Safety of HCP1306 Tablet Versus HGP0816 Tablet in Patients With Primary Hypercholesterolemia","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2014-06","conditions":"Primary Hypercholesterolemia","enrollment":412},{"nctId":"NCT02554136","phase":"PHASE1","title":"Evaluating a Pharmacokinetic Drug Interaction Between HGP0918 and HGP0816","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2015-07","conditions":"Healthy","enrollment":36},{"nctId":"NCT02551172","phase":"PHASE3","title":"Evaluating the Efficacy and Safety of HCP1105 in Combined Hyperlipidemic Patients With High Risk for CHD","status":"UNKNOWN","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2014-10","conditions":"Hyperlipidemias","enrollment":270}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HGP0816","genericName":"HGP0816","companyName":"Hanmi Pharmaceutical Company Limited","companyId":"hanmi-pharmaceutical-company-limited","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HGP0816 is a selective androgen receptor degrader (SARD) that binds to and promotes degradation of the androgen receptor protein. Used for Castration-resistant prostate cancer (CRPC).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}