{"id":"hfo-1234ze-e","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL83060","moleculeType":"Small molecule","molecularWeight":"448.59"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HFO-1234ze(E) serves as an environmentally friendly propellant in inhaled pharmaceutical formulations, enabling aerosolization and delivery of active pharmaceutical ingredients to the lungs. It has a very low global warming potential (GWP) and zero ozone depletion potential (ODP), making it a sustainable alternative to older propellant technologies. The compound itself is pharmacologically inert and functions purely as a delivery mechanism.","oneSentence":"HFO-1234ze(E) is a hydrofluoroolefin (HFO) propellant used in metered-dose inhalers as a replacement for chlorofluorocarbon (CFC) and hydrochlorofluoroalkane (HCFA) propellants.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:11.064Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Propellant for metered-dose inhaler formulations in respiratory diseases (asthma, COPD, and other inhaled therapies)"}]},"trialDetails":[{"nctId":"NCT05755932","phase":"PHASE3","title":"Study to Assess Effect of Next-Generation Propellant MDI on Mucociliary Clearance Vs. HFA Propellant MDI in Healthy Participants","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2023-06-14","conditions":"Mucociliary Clearance","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Propellant in MDI"],"phase":"phase_3","status":"active","brandName":"HFO-1234ze(E)","genericName":"HFO-1234ze(E)","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HFO-1234ze(E) is a hydrofluoroolefin (HFO) propellant used in metered-dose inhalers as a replacement for chlorofluorocarbon (CFC) and hydrochlorofluoroalkane (HCFA) propellants. Used for Propellant for metered-dose inhaler formulations in respiratory diseases (asthma, COPD, and other inhaled therapies).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}