{"id":"hexamidine","rwe":[{"pmid":"41486482","year":"2026","title":"Emergence of PHMB Resistance in Acanthamoeba castellanii and Observations on Cross-Resistance to Other Frontline Therapeutics.","finding":"","journal":"Current eye research","studyType":"Clinical Study"},{"pmid":"41261938","year":"2026","title":"Axillary Contact Dermatitis in an Adult Caused by Hexamidine Diisethionate From Baby Wipes Labelled \"Pure Water\".","finding":"","journal":"Contact dermatitis","studyType":"Clinical Study"},{"pmid":"40659372","year":"2025","title":"Polihexanide (PHMB) 0.08% versus currently used treatments for Acanthamoeba keratitis: indirect treatment comparisons.","finding":"","journal":"BMJ open ophthalmology","studyType":"Clinical Study"},{"pmid":"40322819","year":"2025","title":"Antiseptic activity of different ophthalmic formulations: an in vitro study.","finding":"","journal":"European review for medical and pharmacological sciences","studyType":"Clinical Study"},{"pmid":"40230692","year":"2025","title":"Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"hexamidine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prothrombin","category":"target"},{"label":"F2","category":"gene"},{"label":"ST14","category":"gene"},{"label":"PRSS1","category":"gene"},{"label":"D08AC04","category":"atc"},{"label":"Active","category":"status"},{"label":"Acanthamoeba keratitis","category":"indication"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"desmodine","offLabel":[],"synonyms":["hexamidine","desmodine","hexamidine diisethionate","hexamidine isethionate","hexamidine isetionate","hexamidine dihydrochloride","hexamidine hydrochloride","hexamidine HCl","hexomedin"],"timeline":[],"approvals":[],"brandName":"Desmodine","ecosystem":[{"indication":"Acanthamoeba keratitis","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Prothrombin","targets":[{"gene":"F2","source":"DrugCentral","target":"Prothrombin","protein":"Prothrombin"},{"gene":"ST14","source":"DrugCentral","target":"Suppressor of tumorigenicity 14 protein","protein":"Suppressor of tumorigenicity 14 protein"},{"gene":"PRSS1","source":"DrugCentral","target":"Trypsin-1","protein":"Trypsin-1"},{"gene":"PLAU","source":"DrugCentral","target":"Urokinase-type plasminogen activator","protein":"Urokinase-type plasminogen activator"},{"gene":"PRMT1","source":"DrugCentral","target":"Protein arginine N-methyltransferase 1","protein":"Protein arginine N-methyltransferase 1"}],"modality":"Small Molecule","drugClass":"hexamidine","explanation":"Imagine your body's cells are like a city, and Acanthamoeba parasites are like a virus that infects the city's residents. Desmodine is like a special police officer that stops the virus from spreading and taking over the city. By stopping the virus, Desmodine helps to clear up the infection and heal the city.","oneSentence":"Desmodine works by inhibiting the growth of Acanthamoeba parasites.","technicalDetail":"Desmodine targets prothrombin, a key protein involved in blood clotting, to inhibit the growth of Acanthamoeba parasites."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3275","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=HEXAMIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=HEXAMIDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:52:57.047937","biosimilars":[],"competitors":[{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"hexamidine","indications":{"approved":[{"name":"Acanthamoeba keratitis","source":"DrugCentral","snomedId":231896005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06771908","phase":"","title":"THE ROLE OF HEXAMIDINE DIISETHIONATE (ZAMIDINE®) 1MG/ML 0.6ML EYE DROPS IN THE PROPHYLAXIS OF SURGERY OFTALMIC","status":"RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2025-02-01","conditions":["Eye Disease","Conjunctivitis"],"enrollment":56,"completionDate":"2026-02-01"},{"nctId":"NCT05303805","phase":"PHASE4","title":"Topical Sevoflurane for Treatment of Chronic Leg Ulcers","status":"RECRUITING","sponsor":"Charles University, Czech Republic","startDate":"2022-05-02","conditions":["Leg Ulcer"],"enrollment":50,"completionDate":"2027-01-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005603","UNII":"3483C2H13H","CHEBI":"CHEBI:87184","INN_ID":"1393","RXNORM":"1939371","UMLSCUI":"C0062648","ChEMBL_ID":"CHEMBL25105","KEGG_DRUG":"D07206","DRUGBANK_ID":"DB03808","PDB_CHEM_ID":"DID","PUBCHEM_CID":"65130","SNOMEDCT_US":"703831002","SECONDARY_CAS_RN":"659-40-5","MESH_SUPPLEMENTAL_RECORD_UI":"C018961"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":111,"therapeuticAreas":["Oncology"],"atcClassification":{"source":"DrugCentral","atcCode":"D08AC04","allCodes":["D08AC04","R01AX07","R02AA18","S01AX08","S03AA05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 4","pmid":"41486482","title":"Emergence of PHMB Resistance in Acanthamoeba castellanii and Observations on Cross-Resistance to Other Frontline Therapeutics.","journal":"Current eye research"},{"date":"2026 Feb","pmid":"41261938","title":"Axillary Contact Dermatitis in an Adult Caused by Hexamidine Diisethionate From Baby Wipes Labelled \"Pure Water\".","journal":"Contact dermatitis"},{"date":"2025 Jul 13","pmid":"40659372","title":"Polihexanide (PHMB) 0.08% versus currently used treatments for Acanthamoeba keratitis: indirect treatment comparisons.","journal":"BMJ open ophthalmology"},{"date":"2025 Apr","pmid":"40322819","title":"Antiseptic activity of different ophthalmic formulations: an in vitro study.","journal":"European review for medical and pharmacological sciences"},{"date":"2025","pmid":"40230692","title":"Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis.","journal":"Frontiers in pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desmodine is a small molecule. It is also known by the synonyms HEXAMIDINA, HEXAMIDINE, HEXAMIDINE, HEXAMIDINE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}