{"id":"hesperidin-diosmin-combination-1000","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL231884","moleculeType":"Small molecule","molecularWeight":"608.55"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination works by enhancing vascular endothelial function and reducing inflammatory mediators in the venous system. The flavonoids improve lymphatic drainage and reduce edema by decreasing capillary permeability and increasing venous return. They are commonly used to treat chronic venous insufficiency and related microcirculatory disorders.","oneSentence":"Hesperidin and diosmin are bioflavonoids that improve venous tone and reduce capillary fragility by strengthening blood vessel walls and reducing inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:04.201Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Hemorrhoids"},{"name":"Lymphedema"},{"name":"Microcirculatory disorders"}]},"trialDetails":[{"nctId":"NCT06367166","phase":"NA","title":"Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ryazan State Medical University","startDate":"2023-04-01","conditions":"Varicose Veins of Lower Limb, Varix, Vascular Diseases","enrollment":100},{"nctId":"NCT06584799","phase":"PHASE3","title":"Venoactive Drug Treatment of Pelvic Venous Disorders","status":"RECRUITING","sponsor":"Pirogov Russian National Research Medical University","startDate":"2024-12","conditions":"Pelvic Venous Disorders","enrollment":150},{"nctId":"NCT06546111","phase":"PHASE1, PHASE2","title":"Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection","status":"RECRUITING","sponsor":"Sadat City University","startDate":"2024-10-01","conditions":"Helicobacter Pylori Infection","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hesperidin+Diosmin combination 1000","genericName":"Hesperidin+Diosmin combination 1000","companyName":"Pirogov Russian National Research Medical University","companyId":"pirogov-russian-national-research-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hesperidin and diosmin are bioflavonoids that improve venous tone and reduce capillary fragility by strengthening blood vessel walls and reducing inflammation. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}