{"id":"hes-10","safety":{"commonSideEffects":[{"rate":null,"effect":"Increased bleeding risk"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Coagulopathy"},{"rate":"rare","effect":"Anaphylactic reactions"}]},"_chembl":{"chemblId":"CHEMBL44879","moleculeType":"Small molecule","molecularWeight":"270.37"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HES 10% is a synthetic colloid composed of hydroxyethyl starch dissolved in crystalloid solution. It functions as a volume expander by increasing the oncotic pressure of blood plasma, thereby drawing and retaining fluid in the intravascular space. This mechanism helps restore circulating blood volume in patients with acute blood loss or hypovolemia.","oneSentence":"HES 10% is a hydroxyethyl starch colloid that expands intravascular volume by increasing plasma oncotic pressure to maintain fluid balance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:23:00.039Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemia requiring volume replacement during surgery or trauma"},{"name":"Perioperative fluid management in patients undergoing major surgery"}]},"trialDetails":[{"nctId":"NCT00044304","phase":"PHASE2","title":"Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2002-09-26","conditions":"Eosinophilic Myeloid Neoplasm, Hypereosinophilic Syndrome","enrollment":70},{"nctId":"NCT06768268","phase":"PHASE1, PHASE2","title":"A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green","status":"ENROLLING_BY_INVITATION","sponsor":"National Taiwan University Hospital","startDate":"2025-01-01","conditions":"Breast Cancer Early Stage Breast Cancer (Stage 1-3)","enrollment":30},{"nctId":"NCT06663254","phase":"PHASE4","title":"Safety and Efficacy of Perioperative Volume Replacement with Volulyte 6% in Moderate-to-high Cardiovascular Risk Patients Having Major Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2024-11-30","conditions":"Perioperative Volume Replacement, Hydroxyethyl Starch","enrollment":410},{"nctId":"NCT05142163","phase":"NA","title":"Stroke Volume Variation and Plethysmography Variability Index as Goal Directed Fluid Therapy in Major Oncosurgeries","status":"COMPLETED","sponsor":"Rajiv Gandhi Cancer Institute & Research Center, India","startDate":"2021-11-08","conditions":"Goal Directed Fluid Therapy","enrollment":68},{"nctId":"NCT06259474","phase":"NA","title":"Effect of Hypopressive Exercises on Postpartum Backache and Functional Disability","status":"UNKNOWN","sponsor":"Kafrelsheikh University","startDate":"2024-03-01","conditions":"Low Back Pain","enrollment":47},{"nctId":"NCT05712018","phase":"NA","title":"Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine","status":"COMPLETED","sponsor":"General Hospital of Ningxia Medical University","startDate":"2023-10-20","conditions":"Adverse Effect","enrollment":90},{"nctId":"NCT04733547","phase":"","title":"Spectral Analysis of Central Venous Pressure Waveform","status":"COMPLETED","sponsor":"JongHae Kim","startDate":"2021-02-22","conditions":"Donor Hepatectomy, Central Venous Catheter, Hypovolemia","enrollment":60},{"nctId":"NCT05475990","phase":"NA","title":"Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension","status":"COMPLETED","sponsor":"General Hospital of Ningxia Medical University","startDate":"2023-01-11","conditions":"Adverse Effect","enrollment":80},{"nctId":"NCT01845441","phase":"PHASE2","title":"Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions","status":"TERMINATED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2012-04","conditions":"Stroke, Brain Ischemia, Vasospasm, Intracranial","enrollment":7},{"nctId":"NCT01077895","phase":"PHASE3","title":"The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function","status":"WITHDRAWN","sponsor":"University Hospital, Ghent","startDate":"2010-02","conditions":"Critically Ill, Intra-Abdominal Hypertension, Abdominal Compartment Syndrome","enrollment":""},{"nctId":"NCT04432675","phase":"PHASE4","title":"Effects of Crystal Solution and Colloid Solution on Mother and Fetus","status":"COMPLETED","sponsor":"China International Neuroscience Institution","startDate":"2022-01-30","conditions":"Cesarean Section, Spinal Anesthesia, Parturition","enrollment":100},{"nctId":"NCT04302467","phase":"NA","title":"Effects of Intraoperative Fluid Therapy on Acute Kidney Injury After Thoracoscopic Lobectomy","status":"COMPLETED","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2020-05-01","conditions":"Acute Kidney Injury","enrollment":276},{"nctId":"NCT05154435","phase":"NA","title":"the Effects of Perioperative Goal Directed and Conventional Fluid Management on the IVC Collapsibility Index","status":"COMPLETED","sponsor":"Fatih Sultan Mehmet Training and Research Hospital","startDate":"2021-07-01","conditions":"Femoral Neck Fractures","enrollment":60},{"nctId":"NCT03252496","phase":"NA","title":"Combined Colloids And Crystalloids Versus Crystalloids in Women With Preeclampsia Undergoing Cesarean Delivery","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2017-08-19","conditions":"Pre-Eclampsia, Cesarean Section","enrollment":140},{"nctId":"NCT03262480","phase":"NA","title":"The Stroke Volume Optimization of Goal Directed Fluid Therapy During Radical Cystectomy","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2017-09-01","conditions":"Radical Cystectomy","enrollment":172},{"nctId":"NCT01141894","phase":"NA","title":"Goal Directed Haemodynamic Treatment for Patients With Proximal Femoral Fracture","status":"TERMINATED","sponsor":"Karolinska Institutet","startDate":"2010-03","conditions":"Femoral Fracture","enrollment":150},{"nctId":"NCT03729076","phase":"NA","title":"Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2018-11-16","conditions":"Pregnancy, Cesarean Delivery, Hypotension","enrollment":100},{"nctId":"NCT03677622","phase":"NA","title":"Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery","status":"COMPLETED","sponsor":"Holbaek Sygehus","startDate":"2008-03-01","conditions":"Fluid Overload","enrollment":150},{"nctId":"NCT03630744","phase":"","title":"Fluid Day Spanish Observational Study","status":"UNKNOWN","sponsor":"Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor","startDate":"2019-02","conditions":"Fluid Therapy","enrollment":3500},{"nctId":"NCT02961842","phase":"NA","title":"Combined Colloid Preload And Crystalloid Coload Versus Crystalloid Coload During Spinal Anesthesia for Cesarean Delivery","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2016-11-20","conditions":"Anesthesia, Spinal, Cesarean Section","enrollment":200},{"nctId":"NCT03064880","phase":"NA","title":"Preoperative Goal-directed Fluid Therapy and Physiological Changes Following One-lung Ventilation","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2017-03-15","conditions":"Therapy Adverse Effect","enrollment":60},{"nctId":"NCT01117649","phase":"PHASE4","title":"Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions","status":"COMPLETED","sponsor":"B. Braun Melsungen AG","startDate":"2010-05","conditions":"Plasma Volume Replacement, Surgery of the Pancreatic Head","enrollment":63},{"nctId":"NCT02622126","phase":"PHASE2","title":"Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-01","conditions":"Coagulation Defect; Bleeding","enrollment":60},{"nctId":"NCT00135473","phase":"PHASE3","title":"Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)","status":"COMPLETED","sponsor":"SepNet - Critical Care Trials Group","startDate":"2003-04","conditions":"Severe Sepsis, Septic Shock","enrollment":600},{"nctId":"NCT02277353","phase":"","title":"Evaluation of SVV From NICOM as a Predictor of Fluid Responsiveness in Prone Position During Spine Surgery","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2014-10","conditions":"Fluid Responsiveness, Prone Position, Non Invasive Cardiac Output Monitoring","enrollment":40},{"nctId":"NCT02459470","phase":"NA","title":"Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2012-12","conditions":"Kidney Transplantation","enrollment":42},{"nctId":"NCT01129037","phase":"NA","title":"Goal Directed Fluid Therapy in Free Flap Reconstructive Surgery","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2010-07","conditions":"Head and Neck Cancer","enrollment":78},{"nctId":"NCT01174719","phase":"PHASE4","title":"Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2006-03","conditions":"Valvular Heart Disease, Coronary Artery Disease","enrollment":240},{"nctId":"NCT01965873","phase":"PHASE4","title":"Enteral Nutrition in Acute Pancreatitis","status":"COMPLETED","sponsor":"University Hospital Rijeka","startDate":"2007-05","conditions":"Acute Pancreatitis","enrollment":214},{"nctId":"NCT01473446","phase":"NA","title":"Traditional Versus Goal Directed Perioperative Fluid Therapy in High Risk Patients","status":"TERMINATED","sponsor":"Haukeland University Hospital","startDate":"2012-01","conditions":"Postoperative Complications","enrollment":30},{"nctId":"NCT02337010","phase":"NA","title":"Continuous Central Venous Oxygen Saturation Assisted Intraoperative Hemodynamic Management","status":"COMPLETED","sponsor":"Domonkos Trásy","startDate":"2010-10","conditions":"Major Abdominal Surgery, Perioperative Haemodynamic Monitoring, Perioperative Fluid Management","enrollment":79},{"nctId":"NCT02113358","phase":"NA","title":"Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2014-04","conditions":"Supratentorial Neoplasms, Brain Tumor, Primary, Craniotomy","enrollment":80},{"nctId":"NCT01195025","phase":"NA","title":"Volume Kinetics for Starch Solution and Acetated Ringers","status":"COMPLETED","sponsor":"University Hospital, Linkoeping","startDate":"2010-08","conditions":"Blood Volume, Blood Coagulation","enrollment":10},{"nctId":"NCT02033213","phase":"NA","title":"Volume Restriction in Esophageal Carcinoma Surgery: Randomized Clinical Trial","status":"COMPLETED","sponsor":"Klinički Bolnički Centar Zagreb","startDate":"2011-06","conditions":"Esophageal Neoplasm","enrollment":16},{"nctId":"NCT02056795","phase":"NA","title":"Study of Effects of Electroacupuncture on Balance in Subjects With Chronic Functional Ankle Instability","status":"COMPLETED","sponsor":"Canadian Memorial Chiropractic College","startDate":"2013-01","conditions":"Ankle Sprain","enrollment":24},{"nctId":"NCT01444508","phase":"PHASE4","title":"Effect of Colloid Versus Crystalloid on Coagulation","status":"UNKNOWN","sponsor":"K. C. Rasmussen","startDate":"2011-09","conditions":"Bloodloss","enrollment":40},{"nctId":"NCT00766519","phase":"PHASE4","title":"Effect of Intraoperative Volume Optimization on Outcome After Intrabdominal Surgery","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2009-02","conditions":"Hemodynamic Instability, Surgery","enrollment":104},{"nctId":"NCT01681251","phase":"PHASE1","title":"Goal Directed Therapy for Patients Undergoing Major Vascular Surgery","status":"COMPLETED","sponsor":"University of Manitoba","startDate":"2010-08","conditions":"Abdominal Aortic Aneurysm Uncomplicated","enrollment":40},{"nctId":"NCT01364103","phase":"NA","title":"Study About Predicting Fluid Responsiveness in Children Undergoing Neurosurgery","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2011-02","conditions":"Fluid Responsiveness","enrollment":33},{"nctId":"NCT01041742","phase":"NA","title":"Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2009-12","conditions":"Ischemic Heart Disease","enrollment":35},{"nctId":"NCT00576849","phase":"PHASE4","title":"A Total Balanced Volume Replacement Regimen in Elderly Cardiac Surgery Patients","status":"COMPLETED","sponsor":"Klinikum Ludwigshafen","startDate":"2007-12","conditions":"Elderly, Cardiac Surgery","enrollment":50},{"nctId":"NCT01120730","phase":"PHASE3","title":"Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury","status":"COMPLETED","sponsor":"University of Zurich","startDate":"1997-04","conditions":"Survival, Renal Failure","enrollment":28},{"nctId":"NCT01013090","phase":"NA","title":"Fluid Volume-hypotension Association in Cesarean Under Neuraxial Anesthesia","status":"COMPLETED","sponsor":"Nanjing Medical University","startDate":"2009-07","conditions":"Cesarean Section","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"HES 10%","genericName":"HES 10%","companyName":"B. Braun Melsungen AG","companyId":"b-braun-melsungen-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HES 10% is a hydroxyethyl starch colloid that expands intravascular volume by increasing plasma oncotic pressure to maintain fluid balance. Used for Acute blood loss and hypovolemia requiring volume replacement during surgery or trauma, Perioperative fluid management in patients undergoing major surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}