{"id":"hepavaxgene-thiomersal-free","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL5082715","moleculeType":"Unknown","molecularWeight":"398.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HepavaxGene uses recombinant DNA technology to express hepatitis B surface antigen (HBsAg), which is then formulated as a vaccine to elicit both humoral and cellular immune responses. The thiomersal-free formulation removes the mercury-based preservative while maintaining immunogenicity. This approach aims to provide protective immunity against hepatitis B virus infection.","oneSentence":"HepavaxGene is a recombinant hepatitis B vaccine that stimulates the immune system to produce antibodies against hepatitis B surface antigen.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:01.611Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hepatitis B prevention in infants, children, and adults"}]},"trialDetails":[{"nctId":"NCT01349283","phase":"PHASE3","title":"Immunogenicity and Safety of the Hepatitis B Vaccine Hepavax-Gene TF and a Comparator Hepatitis B Vaccine in Newborns","status":"COMPLETED","sponsor":"Crucell Holland BV","startDate":"2011-05","conditions":"Hepatitis B","enrollment":1738}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HepavaxGene (thiomersal free)","genericName":"HepavaxGene (thiomersal free)","companyName":"Crucell Holland BV","companyId":"crucell-holland-bv","modality":"Biologic","firstApprovalDate":"","aiSummary":"HepavaxGene is a recombinant hepatitis B vaccine that stimulates the immune system to produce antibodies against hepatitis B surface antigen. Used for Hepatitis B prevention in infants, children, and adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}