{"id":"hepatitis-alcohol-probiotics","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance from probiotics"},{"rate":null,"effect":"Withdrawal symptoms during alcohol cessation"}]},"_chembl":{"chemblId":"CHEMBL2108512","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The regimen addresses alcohol-related liver disease through multiple pathways: abstinence from alcohol reduces ongoing hepatotoxicity, hepatitis treatment targets viral or inflammatory components of liver injury, and probiotics restore beneficial gut bacteria that have been depleted by alcohol use and liver disease, thereby reducing bacterial translocation and endotoxemia that perpetuate liver inflammation.","oneSentence":"This is a combination therapeutic approach using alcohol cessation support, hepatitis management, and probiotic supplementation to restore gut microbiota and reduce liver inflammation in patients with alcohol-related hepatitis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:47:33.997Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Alcohol-related hepatitis"},{"name":"Hepatitis with alcohol use disorder"}]},"trialDetails":[{"nctId":"NCT01922895","phase":"NA","title":"Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis","status":"TERMINATED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2013-08-01","conditions":"Acute Alcoholic Hepatitis","enrollment":45},{"nctId":"NCT01501162","phase":"PHASE4","title":"Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease","status":"COMPLETED","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2010-10","conditions":"Alcoholic Liver Disease","enrollment":130},{"nctId":"NCT02335632","phase":"PHASE4","title":"Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis","status":"UNKNOWN","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2012-12","conditions":"Alcoholic Liver Disease","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":71,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["LACTOWELL"],"phase":"marketed","status":"active","brandName":"hepatitis, alcohol, probiotics","genericName":"hepatitis, alcohol, probiotics","companyName":"Chuncheon Sacred Heart Hospital","companyId":"chuncheon-sacred-heart-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination therapeutic approach using alcohol cessation support, hepatitis management, and probiotic supplementation to restore gut microbiota and reduce liver inflammation in patients with alcohol-related hepatitis. Used for Alcohol-related hepatitis, Hepatitis with alcohol use disorder.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}