{"id":"heparin-sodium-lock-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Heparin-induced thrombocytopenia (HIT)"},{"rate":null,"effect":"Local catheter site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Heparin is an anticoagulant that works by binding to and enhancing the activity of antithrombin III, a natural inhibitor of blood coagulation. This complex inactivates several activated clotting factors (particularly thrombin and Factor Xa), preventing the formation and extension of blood clots. When used as a lock solution in catheters, it maintains catheter patency by preventing thrombosis within the device.","oneSentence":"Heparin sodium inhibits blood coagulation by potentiating antithrombin III, which inactivates thrombin and other clotting factors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:58.318Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Maintenance of central venous catheter patency (lock solution)"},{"name":"Prevention of thrombosis in indwelling catheters"}]},"trialDetails":[{"nctId":"NCT07404345","phase":"PHASE4","title":"Low-Dose Apixaban Added to Standard Heparin Lock Versus Heparin Lock Alone to Prevent Tunneled Hemodialysis Catheters Dysfunction (APICATH-HD)","status":"NOT_YET_RECRUITING","sponsor":"Hospital Civil de Guadalajara","startDate":"2026-03-01","conditions":"Hemodialysis Access Failure, Kidney Disease, End-Stage, Hemodialysis Catheter","enrollment":54},{"nctId":"NCT07366372","phase":"NA","title":"Efficacy of Taurolidine Containing Lock Solution for Prevention of Central Venous Catheter Infection in ICU Patients","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-05-01","conditions":"Taurolidine, Lock Solution, Prevention","enrollment":120},{"nctId":"NCT06822426","phase":"PHASE3","title":"Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)","status":"RECRUITING","sponsor":"CorMedix","startDate":"2025-05-14","conditions":"Central Line Associated Blood Stream Infections (CLABSI)","enrollment":200},{"nctId":"NCT05879835","phase":"NA","title":"KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure","status":"RECRUITING","sponsor":"SterileCare Inc.","startDate":"2024-06-21","conditions":"Pediatric Intestinal Failure","enrollment":124},{"nctId":"NCT06714864","phase":"PHASE4","title":"Open-Label Study to Assess Safety and Time to Catheter-related Bloodstream Infections (CRBSI) in Subjects From Birth to < 18 Years of Age","status":"RECRUITING","sponsor":"CorMedix","startDate":"2025-07-08","conditions":"Catheter-Related Infections","enrollment":36},{"nctId":"NCT07074821","phase":"PHASE2","title":"Antimicrobial Locks for Hemodialysis Catheter Infections","status":"COMPLETED","sponsor":"Oman Ministry of Health","startDate":"2023-03-01","conditions":"Catheter Related Blood Stream Infection, Hemodialysis, Vascular Access","enrollment":100},{"nctId":"NCT02651428","phase":"PHASE3","title":"Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection","status":"COMPLETED","sponsor":"CorMedix","startDate":"2015-12","conditions":"Kidney Failure, Chronic, Catheter-Related Infections","enrollment":806},{"nctId":"NCT06707480","phase":"","title":"Expanded Access Program for Patients At Risk for Catheter-related Infections Who Are Not Eligible for DefenCath® Clinical Trials","status":"AVAILABLE","sponsor":"CorMedix","startDate":"","conditions":"Catheter-related Bloodstream Infection","enrollment":""},{"nctId":"NCT06259266","phase":"NA","title":"Catheter Dysfunction Rate in Patients Undergoing Kidney Replacement Therapy. 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Used for Maintenance of central venous catheter patency (lock solution), Prevention of thrombosis in indwelling catheters.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}