{"id":"heparin-50u-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Heparin-induced thrombocytopenia (HIT)"},{"rate":null,"effect":"Thrombosis"},{"rate":null,"effect":"Osteoporosis (with prolonged use)"}]},"_chembl":{"chemblId":"CHEMBL4650299","moleculeType":"Oligosaccharide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Heparin binds to and potentiates antithrombin III, a natural inhibitor of coagulation proteases. This complex rapidly inactivates thrombin (Factor IIa) and Factor Xa, preventing the formation of fibrin clots and the propagation of thrombosis. Heparin is a naturally occurring glycosaminoglycan extracted from animal tissues and acts as an indirect anticoagulant.","oneSentence":"Heparin is an anticoagulant that inhibits blood clotting by enhancing the activity of antithrombin III, which inactivates thrombin and other clotting factors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:47.762Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thromboembolism prophylaxis and treatment"},{"name":"Acute coronary syndrome"},{"name":"Deep vein thrombosis prevention and treatment"},{"name":"Pulmonary embolism treatment"}]},"trialDetails":[{"nctId":"NCT01794767","phase":"PHASE4","title":"Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children","status":"SUSPENDED","sponsor":"University of Florence","startDate":"2013-01","conditions":"Infection of Intravenous Catheter, Phlebitis, Extravasation of Diagnostic and Therapeutic Materials","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Heparin solution 50 U/ml, Epsodilave"],"phase":"marketed","status":"active","brandName":"Heparin 50U/ml","genericName":"Heparin 50U/ml","companyName":"University of Florence","companyId":"university-of-florence","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Heparin is an anticoagulant that inhibits blood clotting by enhancing the activity of antithrombin III, which inactivates thrombin and other clotting factors. Used for Thromboembolism prophylaxis and treatment, Acute coronary syndrome, Deep vein thrombosis prevention and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}