{"id":"hepabulin-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hepabulin IV combines human serum albumin with heparin to create a stabilized complex that extends half-life and improves bioavailability compared to unmodified heparin. The albumin carrier allows for sustained delivery of anticoagulant activity while potentially reducing systemic side effects. This formulation is designed for intravenous administration in thrombotic and inflammatory conditions.","oneSentence":"Hepabulin IV is a human serum albumin-based therapeutic that delivers heparin conjugate to provide anticoagulant and anti-inflammatory effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:15:03.265Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thromboembolism prevention and treatment"},{"name":"Disseminated intravascular coagulation (DIC)"}]},"trialDetails":[{"nctId":"NCT01513850","phase":"PHASE3","title":"A Confirmatory Study of Hepabulin IV in HBsAg Positive Liver Transplantation Recipients","status":"COMPLETED","sponsor":"SK Chemicals Co., Ltd.","startDate":"2010-10","conditions":"Hepatitis B","enrollment":87}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hepabulin IV","genericName":"Hepabulin IV","companyName":"SK Chemicals Co., Ltd.","companyId":"sk-chemicals-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hepabulin IV is a human serum albumin-based therapeutic that delivers heparin conjugate to provide anticoagulant and anti-inflammatory effects. Used for Thromboembolism prevention and treatment, Disseminated intravascular coagulation (DIC).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}