{"id":"hemospan-mp4ox","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Back pain"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MP4OX is a modified hemoglobin molecule conjugated with polyethylene glycol (PEG) to extend its half-life and reduce immunogenicity. It carries and delivers oxygen to tissues similarly to red blood cells, making it useful in situations of acute blood loss or severe anemia where oxygen delivery is compromised. The pegylation allows it to remain in circulation longer than unmodified hemoglobin while minimizing adverse immune and renal effects.","oneSentence":"Hemospan is a pegylated hemoglobin-based oxygen carrier that binds and transports oxygen to tissues, functioning as a blood substitute or oxygen therapeutic.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:03.272Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss / hemorrhagic shock requiring oxygen therapeutic support"},{"name":"Severe anemia in perioperative or trauma settings"}]},"trialDetails":[{"nctId":"NCT00421200","phase":"PHASE3","title":"Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty","status":"COMPLETED","sponsor":"Sangart","startDate":"2007-02","conditions":"Hypotension, Ischemia","enrollment":375},{"nctId":"NCT00425334","phase":"PHASE2","title":"Safety Study of Hemospan® in Prostatectomy Patients","status":"COMPLETED","sponsor":"Sangart","startDate":"2005-07","conditions":"Blood Loss, Surgical, Prostate Cancer, Surgery","enrollment":20},{"nctId":"NCT00494949","phase":"PHASE1, PHASE2","title":"Increasing Dose Safety Study of Hemospan in Orthopedic Surgery Patients","status":"COMPLETED","sponsor":"Sangart","startDate":"2003-04","conditions":"Hypotension, Hypoxia","enrollment":30},{"nctId":"NCT00420277","phase":"PHASE3","title":"Phase III Study of Hemospan® for Treating Hypotension in Hip Arthroplasty","status":"COMPLETED","sponsor":"Sangart","startDate":"2007-02","conditions":"Hypotension, Ischemia","enrollment":462},{"nctId":"NCT00633659","phase":"PHASE2","title":"Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia","status":"COMPLETED","sponsor":"Sangart","startDate":"2007-09","conditions":"Vascular Disease, Critical Lower Limb Ischemia","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MP4OX solution","4.3 g/dL MalPEG-Hb","PEGylated Hb","4.3 g/dL MalPEG Hb"],"phase":"phase_3","status":"active","brandName":"Hemospan (MP4OX)","genericName":"Hemospan (MP4OX)","companyName":"Sangart","companyId":"sangart","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hemospan is a pegylated hemoglobin-based oxygen carrier that binds and transports oxygen to tissues, functioning as a blood substitute or oxygen therapeutic. Used for Acute blood loss / hemorrhagic shock requiring oxygen therapeutic support, Severe anemia in perioperative or trauma settings.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}