{"id":"hemodynamics-based-individualized-antihypertensive-therapy","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL324631","moleculeType":"Small molecule","molecularWeight":"643.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hemodynamics-based individualized antihypertensive therapy is a clinical strategy that uses hemodynamic assessment (such as cardiac output, systemic vascular resistance, and blood pressure patterns) to guide the selection and optimization of antihypertensive medications for individual patients. Rather than a specific pharmaceutical agent, it represents a therapeutic approach where different classes of antihypertensives (ACE inhibitors, beta-blockers, calcium channel blockers, diuretics, etc.) are chosen based on each patient's unique hemodynamic profile to achieve better blood pressure control and clinical outcomes.","oneSentence":"This is a personalized treatment approach that tailors antihypertensive drug selection based on individual hemodynamic profiles rather than a single drug entity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:47:27.333Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension management with personalized hemodynamic profiling"}]},"trialDetails":[{"nctId":"NCT07240909","phase":"PHASE4","title":"Antihypertensive Drug Selection Based on Hemodynamic Phenotypes","status":"NOT_YET_RECRUITING","sponsor":"The Third Xiangya Hospital of Central South University","startDate":"2026-01","conditions":"Hypertension","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["individualized therapy"],"phase":"marketed","status":"active","brandName":"hemodynamics-based individualized antihypertensive therapy","genericName":"hemodynamics-based individualized antihypertensive therapy","companyName":"The Third Xiangya Hospital of Central South University","companyId":"the-third-xiangya-hospital-of-central-south-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a personalized treatment approach that tailors antihypertensive drug selection based on individual hemodynamic profiles rather than a single drug entity. Used for Hypertension management with personalized hemodynamic profiling.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}