{"id":"hematoporphyrin","rwe":[{"pmid":"41858575","year":"2026","title":"Biomimetic Nanoplatform Based on Macrophage Membrane-Coated Fe3O4 Nanoparticles for Synergistic Ferroptosis and Sonodynamic Therapy of Lung Cancer.","finding":"","journal":"International journal of nanomedicine","studyType":"Clinical Study"},{"pmid":"41805322","year":"2026","title":"Sonodynamic Therapy with HMME@AMP Conjugate: Efficient Bactericidal Efficacy through Bacterial Structural Damage and Critical Gene Downregulation in Pathogenic Bacteria.","finding":"","journal":"ACS applied bio materials","studyType":"Clinical Study"},{"pmid":"41752953","year":"2026","title":"5-Aminolevulinic Acid-Based Radiodynamic Therapy for Malignant Gliomas: A Conceptual Framework for Mitochondria-Centered Mechanisms, Target Cell States and Translational Perspectives.","finding":"","journal":"Life (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41733297","year":"2026","title":"Bioengineered Escherichia coli Nissle 1917 with hematoporphyrin monomethyl ether for targeted sonodynamic therapy and immune activation in ovarian cancer.","finding":"","journal":"Journal of materials chemistry. 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Photodyn is like a special kind of paint that, when exposed to light, makes the cancer cells burn up and die. This process is called photodynamic therapy and it's a way to target and kill cancer cells without harming healthy cells.","oneSentence":"Photodyn works by being activated by light, which then kills cancer cells through a process called photodynamic therapy.","technicalDetail":"Photodyn is a photosensitizing agent that, upon activation by light of a specific wavelength, generates reactive oxygen species that induce cell death through apoptosis and necrosis, making it a useful tool in the treatment of various cancers."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Hematoporphyrin","title":"Hematoporphyrin","extract":"Hematoporphyrin is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated. It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3274","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Hematoporphyrin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Hematoporphyrin","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Hematoporphyrin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T13:51:14.915312","biosimilars":[],"competitors":[],"genericName":"hematoporphyrin","indications":{"approved":[{"name":"Endoscopic Photodynamic Ablation Adjunct for Cancer or High Grade Dysplasia","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"High Grade Dysplasia associated with Barrett's 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v8","Solid Tumor"],"enrollment":19,"completionDate":"2024-07-26"},{"nctId":"NCT03727061","phase":"PHASE1","title":"Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer","status":"TERMINATED","sponsor":"Roswell Park Cancer Institute","startDate":"2019-07-10","conditions":["Recurrent Head and Neck Carcinoma","Locally Advanced Head and Neck Carcinoma"],"enrollment":5,"completionDate":"2024-10-22"},{"nctId":"NCT04860154","phase":"NA","title":"Photodynamic Therapy for Cholangiocarcinoma","status":"COMPLETED","sponsor":"Hepatopancreatobiliary Surgery Institute of Gansu Province","startDate":"2021-04-17","conditions":["Cholangiocarcinoma Non-resectable"],"enrollment":86,"completionDate":"2024-11-19"},{"nctId":"NCT06437288","phase":"PHASE4","title":"Hematoporphyrin Photodynamic Therapy for Esophageal Cancer","status":"NOT_YET_RECRUITING","sponsor":"Sun Yat-sen 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Carcinoma"],"enrollment":3,"completionDate":"2016-11-04"},{"nctId":"NCT00453336","phase":"PHASE2","title":"Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract","status":"COMPLETED","sponsor":"University of Miami","startDate":"2003-06","conditions":["Head and Neck Cancer","Precancerous/Nonmalignant Condition"],"enrollment":45,"completionDate":"2010-05"},{"nctId":"NCT00217087","phase":"PHASE2","title":"Endoscopic Therapy of Early Cancer in Barretts Esophagus","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2005-09","conditions":["Early Stage Esophageal Adenocarcinoma","Barrett Esophagus"],"enrollment":73,"completionDate":"2012-06"},{"nctId":"NCT02628665","phase":"PHASE3","title":"Clinical Study of Time Optimizing of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer","status":"UNKNOWN","sponsor":"The First Affiliated Hospital of Henan University of Science and 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Tumors"],"enrollment":1,"completionDate":"2006-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005425","UNII":"HBT6M5H379","CHEBI":"CHEBI:36162","RXNORM":"5164","UMLSCUI":"C0018959","ChEMBL_ID":"CHEMBL317840","DRUGBANK_ID":"DB16183","PUBCHEM_CID":"11103","SNOMEDCT_US":"51462002","MESH_DESCRIPTOR_UI":"D006415"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"Hepatopancreatobiliary Surgery Institute of Gansu Province","relationship":"Current Owner"}],"publicationCount":1956,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026","pmid":"41858575","title":"Biomimetic Nanoplatform Based on Macrophage Membrane-Coated Fe3O4 Nanoparticles for Synergistic Ferroptosis and Sonodynamic Therapy of Lung Cancer.","journal":"International journal of nanomedicine"},{"date":"2026 Mar 10","pmid":"41805322","title":"Sonodynamic Therapy with HMME@AMP Conjugate: Efficient Bactericidal Efficacy through Bacterial Structural Damage and Critical Gene Downregulation in Pathogenic Bacteria.","journal":"ACS applied bio materials"},{"date":"2026 Feb 12","pmid":"41752953","title":"5-Aminolevulinic Acid-Based Radiodynamic Therapy for Malignant Gliomas: A Conceptual Framework for Mitochondria-Centered Mechanisms, Target Cell States and Translational Perspectives.","journal":"Life (Basel, Switzerland)"},{"date":"2026 Mar 5","pmid":"41733297","title":"Bioengineered Escherichia coli Nissle 1917 with hematoporphyrin monomethyl ether for targeted sonodynamic therapy and immune activation in ovarian cancer.","journal":"Journal of materials chemistry. 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Photodyn works by being activated by light, which then kills cancer cells. The commercial status of Photodyn is unclear, but it is approved for use in certain indications. Key safety considerations include the potential for skin and eye irritation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}