{"id":"hdm-slit-tablet-12-sq-hdm","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus / itching"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Mouth edema"},{"rate":null,"effect":"Gastrointestinal symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This sublingual immunotherapy (SLIT) tablet contains standardized house dust mite (HDM) allergen extract that is placed under the tongue, allowing the oral mucosa to present the allergen to immune cells and gradually shift the immune response from allergic (Th2) to tolerant (Treg-mediated). Repeated exposure to small, escalating doses of HDM allergen via this route desensitizes the immune system, reducing allergic symptoms upon natural exposure to house dust mites.","oneSentence":"HDM SLIT-tablet delivers house dust mite allergen extract sublingually to induce immune tolerance through oral mucosal sensitization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:01.130Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"House dust mite allergic rhinitis and/or asthma"}]},"trialDetails":[{"nctId":"NCT07060885","phase":"PHASE3","title":"A Research Study of House Dust Mite (HDM) SLIT-tablet for the Treatment of HDM Allergy in Chinese Participants Aged 12-65","status":"RECRUITING","sponsor":"ALK-Abelló A/S","startDate":"2025-09-01","conditions":"Allergic Rhinoconjunctivitis, Allergic Rhinitis","enrollment":300},{"nctId":"NCT06151938","phase":"","title":"Evaluate Measurement Instruments Relevance in Assessing Effectiveness of ACARIZAX® in House Dust Mite Allergic Rhinitis","status":"ENROLLING_BY_INVITATION","sponsor":"ALK-Abelló A/S","startDate":"2023-11-21","conditions":"Allergic Rhinitis Due to House Dust Mite, Allergic Asthma","enrollment":100},{"nctId":"NCT04176185","phase":"PHASE3","title":"A Research Study in Chinese People With Allergy to House Dust Mites, Using an Environmental Exposure Chamber","status":"TERMINATED","sponsor":"ALK-Abelló A/S","startDate":"2019-11-04","conditions":"Allergic Rhinoconjunctivitis","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HDM SLIT-tablet (12 SQ-HDM)","genericName":"HDM SLIT-tablet (12 SQ-HDM)","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Biologic","firstApprovalDate":"","aiSummary":"HDM SLIT-tablet delivers house dust mite allergen extract sublingually to induce immune tolerance through oral mucosal sensitization. Used for House dust mite allergic rhinitis and/or asthma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}