{"id":"hdm-slit-tablet","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Mouth edema"},{"rate":null,"effect":"Local allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL3653256","moleculeType":"Small molecule","molecularWeight":"555.42"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This sublingual immunotherapy (SLIT) tablet contains standardized house dust mite (HDM) allergen extract that is placed under the tongue, allowing direct mucosal immune exposure. The mechanism involves gradual desensitization of the immune system through induction of regulatory T cells and shift from Th2 to Th1/Treg responses, reducing IgE-mediated allergic inflammation and clinical symptoms.","oneSentence":"HDM SLIT-tablet is a sublingual immunotherapy that delivers house dust mite allergen extract to induce immune tolerance and reduce allergic responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:57.034Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis and/or allergic asthma induced by house dust mite allergen"}]},"trialDetails":[{"nctId":"NCT07060885","phase":"PHASE3","title":"A Research Study of House Dust Mite (HDM) SLIT-tablet for the Treatment of HDM Allergy in Chinese Participants Aged 12-65","status":"RECRUITING","sponsor":"ALK-Abelló A/S","startDate":"2025-09-01","conditions":"Allergic Rhinoconjunctivitis, Allergic Rhinitis","enrollment":300},{"nctId":"NCT05113394","phase":"PHASE2","title":"Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy","status":"WITHDRAWN","sponsor":"Boston Children's Hospital","startDate":"2027-02-01","conditions":"Asthma, Allergy","enrollment":""},{"nctId":"NCT06509243","phase":"NA","title":"Dupilumab and House Dust Mite Immunotherapy in Patients With Atopic Dermatitis","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2023-02-10","conditions":"Atopic Dermatitis","enrollment":132},{"nctId":"NCT04145219","phase":"PHASE3","title":"House Dust Mite Allergy Trial In Children","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2019-10-12","conditions":"Allergic Rhinitis Due to Dermatophagoides Farinae, Allergic Rhinitis Due to Dermatophagoides Pteronyssinus, Allergic Rhinitis Due to House Dust Mite","enrollment":1460},{"nctId":"NCT06151938","phase":"","title":"Evaluate Measurement Instruments Relevance in Assessing Effectiveness of ACARIZAX® in House Dust Mite Allergic Rhinitis","status":"ENROLLING_BY_INVITATION","sponsor":"ALK-Abelló A/S","startDate":"2023-11-21","conditions":"Allergic Rhinitis Due to House Dust Mite, Allergic Asthma","enrollment":100},{"nctId":"NCT03654976","phase":"PHASE3","title":"Mite Asthma Pediatric Immunotherapy Trial","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2018-02-22","conditions":"Allergic Asthma Due to Dermatophagoides Farinae, Allergic Asthma Due to Dermatophagoides Pteronyssinus, Allergic Rhinitis Due to House Dust Mite","enrollment":533},{"nctId":"NCT04541004","phase":"PHASE3","title":"Adolescent Mite Allergy Safety Evaluation","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2020-09-23","conditions":"Allergic Rhinitis, Allergic Rhinoconjunctivitis","enrollment":253},{"nctId":"NCT04176185","phase":"PHASE3","title":"A Research Study in Chinese People With Allergy to House Dust Mites, Using an Environmental Exposure Chamber","status":"TERMINATED","sponsor":"ALK-Abelló A/S","startDate":"2019-11-04","conditions":"Allergic Rhinoconjunctivitis","enrollment":80},{"nctId":"NCT00674700","phase":"PHASE2, PHASE3","title":"Safety and Efficacy Study of Sublingual Immunotherapy (SLIT) to Treat House Dust Mite Allergic Rhinitis","status":"COMPLETED","sponsor":"Stallergenes Greer","startDate":"2007-10","conditions":"Allergic Rhinitis","enrollment":509},{"nctId":"NCT01930461","phase":"PHASE2","title":"Dose Ranging Study of SLIT Tablets of House Dust Mite Allergen Extracts (HDM) in Adults With HDM-associated Allergic Asthma","status":"COMPLETED","sponsor":"Stallergenes Greer","startDate":"2013-09","conditions":"Asthma, House Dust Mite Allergy","enrollment":386},{"nctId":"NCT01608243","phase":"PHASE1","title":"Safety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts","status":"COMPLETED","sponsor":"Stallergenes Greer","startDate":"2012-05","conditions":"Asthma, House Dust Mite Allergy","enrollment":94}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Acarizax","Odactra","ACARIZAX, ODACTRA"],"phase":"phase_3","status":"active","brandName":"HDM SLIT-tablet","genericName":"HDM SLIT-tablet","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Biologic","firstApprovalDate":"","aiSummary":"HDM SLIT-tablet is a sublingual immunotherapy that delivers house dust mite allergen extract to induce immune tolerance and reduce allergic responses. Used for Allergic rhinitis and/or allergic asthma induced by house dust mite allergen.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}