{"id":"hdcv-comparator","safety":{"commonSideEffects":[{"rate":"30-74","effect":"Local injection site reactions (pain, erythema, swelling)"},{"rate":"5-20","effect":"Headache"},{"rate":"5-15","effect":"Myalgia"},{"rate":"1-6","effect":"Fever"},{"rate":"1-5","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL3983509","moleculeType":"Small molecule","molecularWeight":"434.92"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HDCV is an inactivated rabies vaccine produced in human diploid cells (MRC-5 cell line) that contains killed rabies virus antigen. Upon administration, it triggers both humoral and cellular immune responses, leading to the production of rabies-specific antibodies and memory immune cells that protect against rabies virus infection. It is used for both post-exposure prophylaxis and pre-exposure prophylaxis in high-risk populations.","oneSentence":"HDCV (Human Diploid Cell Vaccine) is a rabies vaccine that stimulates the immune system to produce antibodies against rabies virus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:14:55.576Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rabies post-exposure prophylaxis"},{"name":"Rabies pre-exposure prophylaxis in high-risk individuals"}]},"trialDetails":[{"nctId":"NCT06546709","phase":"PHASE1","title":"DMID 23-0015; Lassa Fever CVD 1000","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wilbur Chen, MD, MS","startDate":"2025-01-13","conditions":"Lassa Fever","enrollment":55},{"nctId":"NCT01148459","phase":"PHASE3","title":"Safety and Immunogenicity of GSK Biologicals' Investigational Malaria Vaccine in HIV Infected Infants and Children","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2010-07-30","conditions":"Malaria","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Imovax"],"phase":"phase_3","status":"active","brandName":"HDCV Comparator","genericName":"HDCV Comparator","companyName":"Wilbur Chen, MD, MS","companyId":"wilbur-chen-md-ms","modality":"Biologic","firstApprovalDate":"","aiSummary":"HDCV (Human Diploid Cell Vaccine) is a rabies vaccine that stimulates the immune system to produce antibodies against rabies virus. Used for Rabies post-exposure prophylaxis, Rabies pre-exposure prophylaxis in high-risk individuals.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}