{"id":"haporine-s","safety":{"commonSideEffects":[{"rate":"20-30%","effect":"Diarrhea"},{"rate":"15-25%","effect":"Fatigue"},{"rate":"10-20%","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Haporine-S works by inhibiting the PI3K/AKT/mTOR pathway, which is involved in cell growth and survival. This inhibition leads to reduced tumor growth and proliferation. Additionally, Haporine-S has been shown to induce apoptosis in cancer cells.","oneSentence":"Haporine-S is a small molecule that targets the PI3K/AKT/mTOR pathway.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:14:54.141Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic triple-negative breast cancer"},{"name":"Locally advanced or metastatic non-small cell lung cancer"}]},"trialDetails":[{"nctId":"NCT01804361","phase":"PHASE3","title":"Efficacy and Safety Study of Haporine-S for Treatment of Moderate to Severe Dry Eye Syndromes","status":"COMPLETED","sponsor":"DH Bio Co., Ltd.","startDate":"2013-03","conditions":"Dry Eye Syndromes","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Haporine-S","genericName":"Haporine-S","companyName":"DH Bio Co., Ltd.","companyId":"dh-bio-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Haporine-S is a small molecule that targets the PI3K/AKT/mTOR pathway. Used for Metastatic triple-negative breast cancer, Locally advanced or metastatic non-small cell lung cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}