{"id":"hand-mixed-tobramycin","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Nephrotoxicity"},{"rate":"3-14","effect":"Ototoxicity"},{"rate":null,"effect":"Neuromuscular blockade"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL3989564","moleculeType":"Small molecule","molecularWeight":"1425.44"},"_fixedAt":"2026-03-30T16:14:49.314843","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tobramycin binds irreversibly to the bacterial 30S ribosomal subunit, disrupting the reading of mRNA codons and causing misincorporation of amino acids into proteins. This leads to production of non-functional proteins and ultimately bacterial cell death. It is bactericidal and effective against aerobic gram-negative bacteria and some gram-positive organisms.","oneSentence":"Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:27.528Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Serious gram-negative bacterial infections"},{"name":"Cystic fibrosis-associated Pseudomonas aeruginosa lung infections (inhaled formulation)"}]},"_fixedFields":["pubmed(11)"],"trialDetails":[{"nctId":"NCT03928522","phase":"PHASE4","title":"Antibiotic Elution in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2019-01-28","conditions":"Total Knee Replacement","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"recentPublications":[],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tobramycin"],"phase":"marketed","status":"active","brandName":"hand mixed tobramycin","genericName":"hand mixed tobramycin","companyName":"Washington University School of Medicine","companyId":"washington-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tobramycin is a small molecule that inhibits the 70S ribosome, classified as an inhibitor. It has been studied in the context of total knee replacement, where it was administered in hand-mixed and pre-mixed forms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}