{"id":"hand-antisepsis-with-propanolol-1-60","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propranolol's primary mechanism is beta-blockade of cardiac and vascular adrenergic receptors. When formulated as a 60% topical solution for hand antisepsis, any antimicrobial effect would be incidental or due to the formulation vehicle rather than propranolol's known pharmacology. This appears to be an unconventional or potentially mislabeled product, as propranolol is not a recognized antiseptic agent.","oneSentence":"Propranolol is a non-selective beta-adrenergic receptor antagonist that reduces heart rate and blood pressure; however, its use as a hand antisepsis agent at 60% concentration is non-standard and likely reflects a topical antimicrobial application rather than its typical systemic cardiovascular mechanism.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:47:32.153Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hand antisepsis (non-standard/unconventional use)"}]},"trialDetails":[{"nctId":"NCT04683146","phase":"PHASE4","title":"Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate ( Sorbectol )","status":"UNKNOWN","sponsor":"Centro Ortopedico y Quirurgico del Pie","startDate":"2021-03-10","conditions":"Antisepsis","enrollment":24},{"nctId":"NCT04538365","phase":"PHASE4","title":"Pre-surgical Antisepsis of Hands After Washing With Triclosan 0.5% Compared to Propan-1-ol 60%","status":"COMPLETED","sponsor":"Centro Ortopedico y Quirurgico del Pie","startDate":"2020-10-01","conditions":"Antisepsis","enrollment":24},{"nctId":"NCT04454619","phase":"PHASE4","title":"Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate","status":"COMPLETED","sponsor":"Centro Ortopedico y Quirurgico del Pie","startDate":"2020-07-12","conditions":"Antisepsis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Hand antisepsis with Propanolol- 1 60%.","genericName":"Hand antisepsis with Propanolol- 1 60%.","companyName":"Centro Ortopedico y Quirurgico del Pie","companyId":"centro-ortopedico-y-quirurgico-del-pie","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propranolol is a non-selective beta-adrenergic receptor antagonist that reduces heart rate and blood pressure; however, its use as a hand antisepsis agent at 60% concentration is non-standard and likely reflects a topical antimicrobial application rather than its typical systemic cardiovascular mechanism. Used for Hand antisepsis (non-standard/unconventional use).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}