{"id":"hand-antisepsis-by-scrub","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or dermatitis"},{"rate":null,"effect":"Dryness or scaling"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a procedural antiseptic intervention rather than a pharmaceutical drug. It combines mechanical action (scrubbing) with antimicrobial agents (typically alcohols, chlorhexidine, or iodine-based compounds) to reduce the microbial load on hands before surgical or clinical procedures. The scrubbing action physically dislodges bacteria and viruses while the chemical agents denature microbial cell membranes and proteins.","oneSentence":"Hand antisepsis by scrub mechanically removes and chemically inactivates microorganisms from the skin surface through friction and antimicrobial agents.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:52.945Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preoperative hand antisepsis for surgical personnel"},{"name":"Clinical hand hygiene in healthcare settings"}]},"trialDetails":[{"nctId":"NCT04538365","phase":"PHASE4","title":"Pre-surgical Antisepsis of Hands After Washing With Triclosan 0.5% Compared to Propan-1-ol 60%","status":"COMPLETED","sponsor":"Centro Ortopedico y Quirurgico del Pie","startDate":"2020-10-01","conditions":"Antisepsis","enrollment":24},{"nctId":"NCT04454619","phase":"PHASE4","title":"Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate","status":"COMPLETED","sponsor":"Centro Ortopedico y Quirurgico del Pie","startDate":"2020-07-12","conditions":"Antisepsis","enrollment":24},{"nctId":"NCT04446923","phase":"PHASE4","title":"Surgical Hand Antisepsis With Propan-ol-1 60% Per Rubbing and Scrubbing","status":"COMPLETED","sponsor":"Universidad Complutense de Madrid","startDate":"2020-06-28","conditions":"Skin Diseases, Surgical Site Infection","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":69,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Propanolol"],"phase":"marketed","status":"active","brandName":"Hand antisepsis by scrub","genericName":"Hand antisepsis by scrub","companyName":"Universidad Complutense de Madrid","companyId":"universidad-complutense-de-madrid","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hand antisepsis by scrub mechanically removes and chemically inactivates microorganisms from the skin surface through friction and antimicrobial agents. Used for Preoperative hand antisepsis for surgical personnel, Clinical hand hygiene in healthcare settings.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}