{"id":"haloxazolam","rwe":[{"pmid":"34959674","year":"2021","title":"An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"12519461","year":"2003","title":"Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra.","finding":"","journal":"Psychiatry and clinical neurosciences","studyType":"Clinical Study"},{"pmid":"10022210","year":"1999","title":"Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"},{"pmid":"8832439","year":"1996","title":"Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.","finding":"","journal":"Journal of chromatography. B, Biomedical applications","studyType":"Clinical Study"},{"pmid":"7581920","year":"1995","title":"Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography.","finding":"","journal":"Journal of chromatography. B, Biomedical applications","studyType":"Clinical Study"}],"tags":[{"label":"haloxazolam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"somelin","offLabel":[],"synonyms":["haloxazolam","somelin"],"timeline":[],"approvals":[],"brandName":"Somelin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"haloxazolam","explanation":"Imagine your brain is like a busy city with lots of people talking and moving around. GABA is like a traffic cop that helps to slow down the traffic and keep everything calm. Somelin helps the traffic cop do its job more effectively, which can help to reduce feelings of anxiety and promote relaxation.","oneSentence":"Somelin works by enhancing the activity of a neurotransmitter called GABA, which helps to calm the brain and reduce anxiety.","technicalDetail":"Haloxazolam acts as a positive allosteric modulator of the GABA_A receptor, increasing the frequency of chloride channel opening and enhancing the inhibitory effects of GABA on neuronal activity."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Haloxazolam","title":"Haloxazolam","extract":"Haloxazolam, is a drug which is a benzodiazepine derivative. It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment of insomnia. A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1357","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=HALOXAZOLAM","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Haloxazolam","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T13:51:00.383106","biosimilars":[],"competitors":[],"genericName":"haloxazolam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"M448L2V8XP","CHEBI":"CHEBI:31666","INN_ID":"4295","UMLSCUI":"C0120735","ChEMBL_ID":"CHEMBL2104461","KEGG_DRUG":"D01758","DRUGBANK_ID":"DB01476","PUBCHEM_CID":"3563","MESH_SUPPLEMENTAL_RECORD_UI":"C018779"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2021 Dec 6","pmid":"34959674","title":"An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2003 Feb","pmid":"12519461","title":"Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra.","journal":"Psychiatry and clinical neurosciences"},{"date":"1999 Jan-Feb","pmid":"10022210","title":"Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine.","journal":"Journal of analytical toxicology"},{"date":"1996 Jun 28","pmid":"8832439","title":"Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.","journal":"Journal of chromatography. B, Biomedical applications"},{"date":"1995 Jul 21","pmid":"7581920","title":"Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography.","journal":"Journal of chromatography. B, Biomedical applications"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Somelin is a small molecule. It is also known by the synonyms HALOXAZOLAM and SOMELIN.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}