{"id":"haloprogin","rwe":[],"tags":[{"label":"haloprogin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Adenosine receptor A3","category":"target"},{"label":"ADORA3","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"ADRA2B","category":"gene"},{"label":"D01AE11","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Tinea corporis","category":"indication"},{"label":"Tinea cruris","category":"indication"},{"label":"Tinea pedis","category":"indication"},{"label":"Westwood Squibb","category":"company"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"Westwood Squibb","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=HALOPROGIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:12:41.910572+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T03:13:05.669394+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:12:49.034255+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=HALOPROGIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:12:49.991339+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Cell membrane inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:12:50.558825+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1289/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:12:50.458747+00:00"}},"allNames":["haloprogine","haloprogin"],"offLabel":[],"synonyms":["haloprogine","haloprogin"],"timeline":[],"aiSummary":"Haloprogin, marketed by Westwood Squibb, is an antifungal agent indicated for the treatment of tinea corporis, competing in a class with several off-patent generics and one drug with an unknown patent status. Its unique mechanism of action, binding to the adenosine receptor A3 to inhibit fungal growth, sets it apart from other antifungals in the same class. The primary risk to Haloprogin's market position is the key composition patent expiry in 2028, which could lead to increased competition from generics.","approvals":[{"date":"","orphan":false,"company":"WESTWOOD SQUIBB","regulator":"FDA"}],"ecosystem":[{"indication":"Tinea corporis","otherDrugs":[{"name":"benzocaine","slug":"benzocaine","company":""},{"name":"betamethasone","slug":"betamethasone","company":""},{"name":"betamethasone dipropionate","slug":"betamethasone-dipropionate","company":"Schering"},{"name":"butenafine","slug":"butenafine","company":"Mylan"}],"globalPrevalence":null},{"indication":"Tinea cruris","otherDrugs":[{"name":"betamethasone","slug":"betamethasone","company":""},{"name":"betamethasone dipropionate","slug":"betamethasone-dipropionate","company":"Schering"},{"name":"butenafine","slug":"butenafine","company":"Mylan"},{"name":"ciclopirox","slug":"ciclopirox","company":"Medimetriks Pharms"}],"globalPrevalence":null},{"indication":"Tinea 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transporter"},{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"},{"gene":"OPRK1","source":"DrugCentral","target":"Kappa-type opioid receptor","protein":"Kappa-type opioid receptor"},{"gene":"TACR2","source":"DrugCentral","target":"Substance-K receptor","protein":"Substance-K receptor"},{"gene":"GALE","source":"DrugCentral","target":"UDP-glucose 4-epimerase","protein":"UDP-glucose 4-epimerase"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"}],"modality":"Small Molecule","drugClass":"haloprogin","explanation":"","oneSentence":"","technicalDetail":"Haloprogin acts as a competitive antagonist at the adenosine receptor A3, which is involved in the regulation of fungal growth and 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