{"id":"halopredone-acetate","rwe":[{"pmid":"11161290","year":"2001","title":"Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells.","finding":"","journal":"Analytical biochemistry","studyType":"Clinical Study"},{"pmid":"1705288","year":"1990","title":"Allergic rhinitis model with Brown Norway rat and evaluation of antiallergic drugs.","finding":"","journal":"Journal of pharmacobio-dynamics","studyType":"Clinical Study"},{"pmid":"3761405","year":"1986","title":"A fifty-two-week chronic toxicity study of halopredone acetate (THS-201) in dogs.","finding":"","journal":"The Journal of toxicological sciences","studyType":"Clinical Study"},{"pmid":"4068064","year":"1985","title":"[Teratogenicity study on halopredone acetate in rats].","finding":"","journal":"The Journal of toxicological sciences","studyType":"Clinical Study"},{"pmid":"4068063","year":"1985","title":"[Fertility study on halopredone acetate in rats].","finding":"","journal":"The Journal of toxicological sciences","studyType":"Clinical Study"}],"tags":[{"label":"halopredone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Glucocorticoid receptor","category":"target"},{"label":"NR3C1","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"haloart","offLabel":[],"synonyms":["THS-201","halopredone acetate","alopredone","haloart"],"timeline":[],"approvals":[],"brandName":"Haloart","ecosystem":[],"mechanism":{"target":"Glucocorticoid receptor","targets":[{"gene":"NR3C1","source":"DrugCentral","target":"Glucocorticoid receptor","protein":"Glucocorticoid receptor"}],"modality":"Small Molecule","drugClass":"halopredone","explanation":"Think of the glucocorticoid receptor like a switch that controls how the body responds to stress and inflammation. When Haloart binds to this switch, it can help to reduce inflammation and other symptoms associated with certain medical conditions. This can be helpful for people who are experiencing conditions like arthritis or asthma.","oneSentence":"Haloart works by binding to the glucocorticoid receptor, a protein that regulates the body's response to stress and inflammation.","technicalDetail":"Haloart exerts its effects by competitively binding to the glucocorticoid receptor, thereby inhibiting the transcription of genes involved in the inflammatory response and modulating the activity of various immune cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1354","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=HALOPREDONE ACETATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:51:29.252959","biosimilars":[],"competitors":[{"drugName":"alclometasone dipropionate","drugSlug":"alclometasone-dipropionate","fdaApproval":"1982-12-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amcinonide","drugSlug":"amcinonide","fdaApproval":"1979-10-18","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"auranofin","drugSlug":"auranofin","fdaApproval":"1985-05-24","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"beclometasone dipropionate","drugSlug":"beclometasone-dipropionate","fdaApproval":"1976-05-12","relationship":"same-target"},{"drugName":"betamethasone","drugSlug":"betamethasone","fdaApproval":"1961-04-17","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"betamethasone acetate","drugSlug":"betamethasone-acetate","fdaApproval":"1965-03-03","relationship":"same-target"},{"drugName":"betamethasone 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acetate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alclometasone-dipropionate","brandName":"alclometasone dipropionate","genericName":"alclometasone dipropionate","approvalYear":"1982","relationship":"same-target"},{"drugId":"amcinonide","brandName":"amcinonide","genericName":"amcinonide","approvalYear":"1979","relationship":"same-target"},{"drugId":"auranofin","brandName":"auranofin","genericName":"auranofin","approvalYear":"1985","relationship":"same-target"},{"drugId":"beclometasone-dipropionate","brandName":"beclometasone dipropionate","genericName":"beclometasone dipropionate","approvalYear":"1976","relationship":"same-target"},{"drugId":"betamethasone","brandName":"betamethasone","genericName":"betamethasone","approvalYear":"1961","relationship":"same-target"},{"drugId":"betamethasone-acetate","brandName":"betamethasone acetate","genericName":"betamethasone acetate","approvalYear":"1965","relationship":"same-target"},{"drugId":"betamethasone-benzoate","brandName":"betamethasone benzoate","genericName":"betamethasone benzoate","approvalYear":"","relationship":"same-target"},{"drugId":"betamethasone-dipropionate","brandName":"betamethasone dipropionate","genericName":"betamethasone dipropionate","approvalYear":"1975","relationship":"same-target"},{"drugId":"betamethasone-phosphate","brandName":"betamethasone phosphate","genericName":"betamethasone phosphate","approvalYear":"1965","relationship":"same-target"},{"drugId":"betamethasone-valerate","brandName":"betamethasone valerate","genericName":"betamethasone valerate","approvalYear":"1967","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"24NUL39JY1","CHEBI":"CHEBI:31665","INN_ID":"4077","UMLSCUI":"C0062105","ChEMBL_ID":"CHEMBL2106520","KEGG_DRUG":"D01743","PUBCHEM_CID":"91667","SECONDARY_CAS_RN":"57781-15-4","MESH_SUPPLEMENTAL_RECORD_UI":"C015912"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2001 Feb 1","pmid":"11161290","title":"Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells.","journal":"Analytical biochemistry"},{"date":"1990 Jul","pmid":"1705288","title":"Allergic rhinitis model with Brown Norway rat and evaluation of antiallergic drugs.","journal":"Journal of pharmacobio-dynamics"},{"date":"1986 May","pmid":"3761405","title":"A fifty-two-week chronic toxicity study of halopredone acetate (THS-201) in dogs.","journal":"The Journal of toxicological sciences"},{"date":"1985 Aug","pmid":"4068064","title":"[Teratogenicity study on halopredone acetate in rats].","journal":"The Journal of toxicological sciences"},{"date":"1985 Aug","pmid":"4068063","title":"[Fertility study on halopredone acetate in rats].","journal":"The Journal of toxicological sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Haloart, also known as halopredone acetate, is a small molecule halopredone that targets the glucocorticoid receptor. Its mechanism of action and commercial status are not well-documented, and it is unclear if it is FDA-approved or off-patent. As a result, there is limited information available on its approved indications, half-life, and bioavailability. Further research is needed to fully understand the properties and uses of Haloart. It is not currently possible to provide a comprehensive summary of this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}