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This combination is used to rapidly manage acute agitation and psychotic symptoms.","oneSentence":"Haloperidol blocks dopamine receptors to reduce psychotic symptoms, while lorazepam enhances GABA signaling to provide sedation and anxiolysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:31:49.656Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute agitation and psychosis"},{"name":"Acute behavioral disturbance in psychotic disorders"}]},"trialDetails":[{"nctId":"NCT01949662","phase":"PHASE2","title":"Haloperidol and Lorazepam for Delirium in Patients With Advanced Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2014-01","conditions":"Advanced Cancers","enrollment":93},{"nctId":"NCT03743649","phase":"PHASE2, PHASE3","title":"Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2019-07-17","conditions":"Delirium, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm","enrollment":110},{"nctId":"NCT06370442","phase":"PHASE3","title":"Intranasal Dexmedetomidine vs. Standard of Care for Emergency Department (ED) Procedural Sedation in the Older Adult","status":"NOT_YET_RECRUITING","sponsor":"State University of New York - 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