{"id":"haloperidol-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Extrapyramidal symptoms (haloperidol)"},{"rate":null,"effect":"Dissociation and emergence reactions (ketamine)"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a combination used in anesthesia and acute psychiatric settings. Haloperidol is a typical antipsychotic that antagonizes dopamine signaling in the mesolimbic and mesocortical pathways, reducing hallucinations and delusions. Ketamine is a dissociative anesthetic and NMDA receptor antagonist that produces rapid sedation, analgesia, and dissociation, often used to complement antipsychotic therapy in acute agitation or psychotic crises requiring sedation.","oneSentence":"Haloperidol blocks dopamine D2 receptors to reduce psychotic symptoms, while ketamine antagonizes NMDA glutamate receptors to provide rapid-onset anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:06.979Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute agitation and psychosis requiring rapid sedation"},{"name":"Perioperative anesthesia in patients with psychotic disorders"}]},"trialDetails":[{"nctId":"NCT04081545","phase":"PHASE3","title":"Effect of Opioid Free Anesthetic on Post-Operative Opioid Consumption After Laparoscopic Bariatric Surgery","status":"COMPLETED","sponsor":"Christine Oryhan","startDate":"2019-12-24","conditions":"Opioid Use, Unspecified, Bariatric Surgery Candidate, Anesthesia","enrollment":181},{"nctId":"NCT03375671","phase":"PHASE2","title":"Rapid Agitation Control With Ketamine in the Emergency Department","status":"COMPLETED","sponsor":"David Barbic","startDate":"2018-05-29","conditions":"Violent Aggressive Behavior, Ketamine","enrollment":81},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":"Postoperative Nausea and Vomiting","enrollment":27034},{"nctId":"NCT02433041","phase":"PHASE4","title":"Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2013-07","conditions":"Postoperative Delirium","enrollment":200},{"nctId":"NCT02909465","phase":"PHASE4","title":"Reducing Ketamine-Induced Agitation, by Midazolam or Haloperidol Premedication After Adult Procedural Sedation","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2016-07","conditions":"Ketamine Induced Agitation","enrollment":185},{"nctId":"NCT02103881","phase":"PHASE4","title":"Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital","status":"WITHDRAWN","sponsor":"Hennepin Healthcare Research Institute","startDate":"2014-04","conditions":"Agitation","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Haloperidol + Ketamine","genericName":"Haloperidol + Ketamine","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Haloperidol blocks dopamine D2 receptors to reduce psychotic symptoms, while ketamine antagonizes NMDA glutamate receptors to provide rapid-onset anesthesia and analgesia. Used for Acute agitation and psychosis requiring rapid sedation, Perioperative anesthesia in patients with psychotic disorders.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}