{"id":"half-dose-depot-triptorelin","safety":{"commonSideEffects":[{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Decreased libido"},{"rate":null,"effect":"Erectile dysfunction"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triptorelin is a synthetic GnRH agonist that initially stimulates the pituitary gland but with continuous exposure causes downregulation of GnRH receptors, resulting in sustained suppression of gonadal hormone secretion. The half-dose depot formulation provides prolonged hormone suppression with a reduced drug load compared to standard-dose formulations, potentially improving tolerability while maintaining therapeutic efficacy.","oneSentence":"Half-dose depot triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:36:52.995Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced prostate cancer"},{"name":"Hormone-responsive breast cancer"},{"name":"Endometriosis"},{"name":"Uterine fibroids"}]},"trialDetails":[{"nctId":"NCT00461916","phase":"PHASE4","title":"Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2005-05","conditions":"Infertility","enrollment":182}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Half-Dose Depot Triptorelin","genericName":"Half-Dose Depot Triptorelin","companyName":"Tehran University of Medical Sciences","companyId":"tehran-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Half-dose depot triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. Used for Advanced prostate cancer, Hormone-responsive breast cancer, Endometriosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}