{"id":"haematopoietic-growth-factor","safety":{"commonSideEffects":[{"rate":null,"effect":"Bone pain"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Thrombosis (with EPO)"}]},"_chembl":{"chemblId":"CHEMBL4297796","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These factors bind to specific receptors on hematopoietic progenitor cells in the bone marrow, triggering proliferation, differentiation, and maturation of blood cell lineages. Common examples include erythropoietin (EPO) for red blood cell production and granulocyte colony-stimulating factor (G-CSF) for white blood cell production. They are used to counteract bone marrow suppression from chemotherapy or to treat various blood disorders.","oneSentence":"Haematopoietic growth factors stimulate the bone marrow to produce and release blood cells, including red blood cells, white blood cells, and platelets.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:47.561Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced neutropenia"},{"name":"Anemia of chronic disease"},{"name":"Bone marrow failure syndromes"}]},"trialDetails":[{"nctId":"NCT04685616","phase":"PHASE3","title":"Brentuximab Vedotin in Early Stage Hodgkin Lymphoma","status":"RECRUITING","sponsor":"University College, London","startDate":"2022-04-14","conditions":"Hodgkin Lymphoma","enrollment":1042},{"nctId":"NCT06608303","phase":"NA","title":"Macrophage Stimulating Factor in the Treatment of Diabetic Wounds","status":"COMPLETED","sponsor":"Peking University Third Hospital","startDate":"2024-10-12","conditions":"Diabetic Wound","enrollment":40},{"nctId":"NCT05594433","phase":"PHASE1","title":"Donation of Whole Blood by Healthy Volunteers After Mobilisation by Haematopoietic Growth Factor (Rhu-G-CSF = Granocyte)","status":"RECRUITING","sponsor":"CellProthera","startDate":"2015-09-10","conditions":"Healthy Volunteers","enrollment":40},{"nctId":"NCT06449625","phase":"PHASE2","title":"Semaglutide in Auto-HSCT","status":"NOT_YET_RECRUITING","sponsor":"Klaus Gottlob Müller","startDate":"2024-08-12","conditions":"Intestinal Mucositis, Inflammation, Chemotherapeutic Toxicity","enrollment":40},{"nctId":"NCT03188172","phase":"PHASE2","title":"MUK Nine b: OPTIMUM Treatment Protocol","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Leeds","startDate":"2017-09-28","conditions":"Multiple Myeloma","enrollment":95},{"nctId":"NCT02947438","phase":"PHASE3","title":"Biosimilar Erythropoietin in Anaemia Treatment (Maintenance Phase Study)","status":"COMPLETED","sponsor":"Shenyang Sunshine Pharmaceutical Co., LTD.","startDate":"2015-12","conditions":"Renal Anemia","enrollment":207},{"nctId":"NCT02522975","phase":"PHASE4","title":"Biosimilar Erythropoietin in Anaemia Treatment (Correction Phase Study)","status":"TERMINATED","sponsor":"Shenyang Sunshine Pharmaceutical Co., LTD.","startDate":"2015-08","conditions":"Renal Anaemia","enrollment":16},{"nctId":"NCT00245037","phase":"PHASE1, PHASE2","title":"Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer","status":"COMPLETED","sponsor":"OHSU Knight Cancer Institute","startDate":"2005-06","conditions":"Chronic Myeloproliferative Disorders, Leukemia, Lymphoma","enrollment":147},{"nctId":"NCT02323789","phase":"PHASE1, PHASE2","title":"Mesenchymal Stromal Cells in Adults With Recessive Dystrophic Epidermolysis Bullosa","status":"UNKNOWN","sponsor":"King's College London","startDate":"2015-06","conditions":"Recessive Dystrophic Epidermolysis Bullosa","enrollment":10},{"nctId":"NCT01016795","phase":"PHASE2","title":"Stem Cell Factor (SCF) Priming of Haematopoietic Stem Cell Grafts in Malignant Lymphoma","status":"TERMINATED","sponsor":"Aalborg University Hospital","startDate":"1999-01","conditions":"Malignant Lymphoma","enrollment":32},{"nctId":"NCT00117442","phase":"PHASE2","title":"A Study of Carboplatin/Paclitaxel With Pegfilgrastim Supported by Haematopoietic Progenitor Cell Re-Infusion in Whole Blood","status":"COMPLETED","sponsor":"Amgen","startDate":"2002-08","conditions":"Breast Cancer, Lung Cancer, Ovarian Cancer","enrollment":61},{"nctId":"NCT00124111","phase":"PHASE2","title":"A Study of Cyclophosphamide/Methotrexate/5-Fluorouracil (CMF) With Pegfilgrastim in Subjects With Breast Cancer","status":"COMPLETED","sponsor":"Amgen","startDate":"","conditions":"Breast Cancer","enrollment":""},{"nctId":"NCT00117897","phase":"PHASE2","title":"Treatment for Subjects With Non-Hodgkin's Lymphoma","status":"COMPLETED","sponsor":"Amgen","startDate":"2002-07","conditions":"Non-Hodgkin's Lymphoma","enrollment":""},{"nctId":"NCT00400556","phase":"PHASE1","title":"ATRA Plus G-CSF for Mobilization of Hematopoietic Stem and Progenitor Cells","status":"COMPLETED","sponsor":"Peter MacCallum Cancer Centre, Australia","startDate":"2005-03","conditions":"Multiple Myeloma, Cutaneous Lymphoma","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Filgrastim","G-CSF","Pegfilgrastim"],"phase":"phase_3","status":"active","brandName":"Haematopoietic growth factor","genericName":"Haematopoietic growth factor","companyName":"University College, London","companyId":"university-college-london","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Haematopoietic growth factors stimulate the bone marrow to produce and release blood cells, including red blood cells, white blood cells, and platelets. Used for Chemotherapy-induced neutropenia, Anemia of chronic disease, Bone marrow failure syndromes.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}