{"id":"gynodian-depot-bay86-5032","safety":{"commonSideEffects":[{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Vaginal dryness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Mood changes / depression"},{"rate":null,"effect":"Decreased bone mineral density"}]},"_chembl":{"chemblId":"CHEMBL586014","moleculeType":"Small molecule","molecularWeight":"366.46"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BAY86-5032 is a depot formulation designed for extended-release delivery of a GnRH agonist, which works by initially stimulating then desensitizing GnRH receptors on pituitary gonadotroph cells. This leads to sustained suppression of gonadal sex hormone production, creating a hypogonadal state useful in hormone-dependent conditions. The depot formulation allows for less frequent dosing compared to shorter-acting GnRH agonists.","oneSentence":"Gynodian Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce estrogen levels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:44.742Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Endometriosis"},{"name":"Uterine fibroids (leiomyomas)"}]},"trialDetails":[{"nctId":"NCT00463450","phase":"PHASE3","title":"Efficacy of Gynodian® Depot in Women With Impaired Well-being","status":"COMPLETED","sponsor":"Bayer","startDate":"2002-05","conditions":"Hormone Replacement Therapy","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Gynodian® Depot (BAY86-5032)","genericName":"Gynodian® Depot (BAY86-5032)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gynodian Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce estrogen levels. Used for Endometriosis, Uterine fibroids (leiomyomas).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}