{"id":"gynodaktarin","safety":{"commonSideEffects":[{"rate":null,"effect":"Vulvovaginal irritation"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Local erythema"}]},"_chembl":{"chemblId":"CHEMBL91","moleculeType":"Small molecule","molecularWeight":"416.13"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug belongs to the imidazole class of antifungals and works by inhibiting the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, which is essential for ergosterol production. Ergosterol is a critical component of the fungal cell membrane; its depletion leads to membrane instability, leakage, and ultimately fungal cell death. This mechanism makes it effective against various dermatophytes and Candida species.","oneSentence":"GYNODAKTARIN is an antifungal agent that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:14:44.777Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal candidiasis"},{"name":"Dermatophyte infections (tinea pedis, tinea corporis, tinea cruris)"}]},"trialDetails":[{"nctId":"NCT02515656","phase":"PHASE3","title":"Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis","status":"COMPLETED","sponsor":"Laboratoire Innotech International","startDate":"2015-09","conditions":"Vaginitis","enrollment":661}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"GYNODAKTARIN®","genericName":"GYNODAKTARIN®","companyName":"Laboratoire Innotech International","companyId":"laboratoire-innotech-international","modality":"Small molecule","firstApprovalDate":"","aiSummary":"GYNODAKTARIN is an antifungal agent that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Vaginal candidiasis, Dermatophyte infections (tinea pedis, tinea corporis, tinea cruris).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}