{"id":"gw685698x-aqueous-nasal-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL14012","moleculeType":"Small molecule","molecularWeight":"218.30"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MCH is a neuropeptide that promotes feeding behavior and energy storage. By antagonizing MCH-R1 receptors in the brain, GW685698X decreases appetite signals, leading to reduced caloric intake and potential weight loss. The nasal spray formulation allows direct delivery to the central nervous system.","oneSentence":"GW685698X is a selective melanin-concentrating hormone receptor 1 (MCH-R1) antagonist that reduces appetite and food intake by blocking MCH signaling in the hypothalamus.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:14:43.764Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Obesity or overweight with weight-related comorbidities"}]},"trialDetails":[{"nctId":"NCT00363740","phase":"PHASE3","title":"Study of GW685698X In Patients With Seasonal Allergic Rhinitis","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-02-19","conditions":"Rhinitis, Allergic, Seasonal","enrollment":38},{"nctId":"NCT00289198","phase":"PHASE3","title":"Once-Daily Investigational Nasal Spray In Adults And Adolescents With Perennial Allergic Rhinitis (PAR)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-02-07","conditions":"Rhinitis, 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