{"id":"gw679769-casopitant","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL1672054","moleculeType":"Small molecule","molecularWeight":"616.62"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Casopitant selectively antagonizes the NK1 receptor, which is involved in the emetic pathway triggered by chemotherapy agents. By blocking substance P, a key neurotransmitter in nausea and vomiting pathways, the drug reduces both acute and delayed chemotherapy-induced nausea and vomiting (CINV). It is often used as part of a combination antiemetic regimen with 5-HT3 antagonists and corticosteroids.","oneSentence":"Casopitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the brain to prevent chemotherapy-induced nausea and vomiting.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:44.296Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy"}]},"trialDetails":[{"nctId":"NCT00601172","phase":"PHASE3","title":"A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-03-10","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":710},{"nctId":"NCT00334646","phase":"PHASE1","title":"Cyclophosphamide Drug Interaction Study In Cancer 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Vomiting","enrollment":515},{"nctId":"NCT00358410","phase":"PHASE2","title":"An Exploratory Study Examining The Effects Of Taking GW679769 Once-Daily For 4 Days In Patients With Functional Dyspepsia","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-01","conditions":"Nonulcer Dyspepsia","enrollment":13},{"nctId":"NCT00108095","phase":"PHASE2","title":"A Study To Evaluate An NK-1 Antiemetic For The Prevention Of Post Operative Nausea And Vomiting","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2004-10","conditions":"Postoperative Nausea and Vomiting, Nausea and Vomiting, Postoperative","enrollment":701},{"nctId":"NCT00321477","phase":"PHASE2","title":"A Study Of GW679769 Compared To Placebo In Women With Overactive Bladder","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-12","conditions":"Incontinence, Urinary and Urinary Bladder, Overactive, Overactive Bladder","enrollment":160},{"nctId":"NCT00274690","phase":"PHASE2","title":"Post-Operative Nausea And Vomiting Study In Female Patients","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-02","conditions":"Postoperative Nausea and Vomiting, Nausea and Vomiting, Postoperative","enrollment":435},{"nctId":"NCT00413023","phase":"PHASE2","title":"Study Of The Effects Of A New Antidepressant Therapy In Patients With Major Depressive Disorder (MDD)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-06","conditions":"Depressive Disorder, Major","enrollment":348},{"nctId":"NCT00273039","phase":"PHASE2","title":"A Study Of A New Medicine (GW679769) For The Treatment Of Social Anxiety Disorder","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-08","conditions":"Social Anxiety Disorder, Anxiety Disorders","enrollment":242},{"nctId":"NCT00326248","phase":"PHASE3","title":"Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In 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Used for Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}