{"id":"guo-na-fen-gonal-f","safety":{"commonSideEffects":[{"rate":"1-10%","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-15%","effect":"Injection site reactions (pain, bruising, redness)"},{"rate":"10-20%","effect":"Abdominal pain or bloating"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Ovarian cysts"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gonal-F (follitropin alfa) is a recombinant human FSH that binds to FSH receptors on ovarian granulosa cells, promoting follicle development and maturation. This leads to increased estrogen production and the development of multiple mature oocytes, which are then retrieved for in vitro fertilization or other assisted reproductive techniques.","oneSentence":"Gonal-F is a recombinant follicle-stimulating hormone (FSH) that stimulates the ovaries to produce multiple eggs for assisted reproductive procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:36:51.989Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility in women undergoing assisted reproductive technology (ART) procedures"},{"name":"Anovulation in women with polycystic ovary syndrome (PCOS)"},{"name":"Male infertility (hypogonadotropic hypogonadism)"}]},"trialDetails":[{"nctId":"NCT06921395","phase":"PHASE4","title":"Phase IV Study to Evaluate the Efficacy and Safety of Fang Le Shu Compared to Guo Na Fen for Controlled Ovarian Stimulation in Infertile Women Undergoing in Vitro Fertilization-embryo Transfer (IVF-ET).","status":"RECRUITING","sponsor":"LG Chem","startDate":"2025-02-15","conditions":"Female Infertility","enrollment":248}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Guo Na Fen (Gonal-F)","genericName":"Guo Na Fen (Gonal-F)","companyName":"LG Chem","companyId":"lg-chem","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gonal-F is a recombinant follicle-stimulating hormone (FSH) that stimulates the ovaries to produce multiple eggs for assisted reproductive procedures. Used for Infertility in women undergoing assisted reproductive technology (ART) procedures, Anovulation in women with polycystic ovary syndrome (PCOS), Male infertility (hypogonadotropic hypogonadism).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}