{"id":"guanazodine","rwe":[{"pmid":"654922","year":"1978","title":"[Determination of guanazodine and guanetidin in Sanegyt and Sanotensin preparations].","finding":"","journal":"Acta pharmaceutica Hungarica","studyType":"Clinical Study"},{"pmid":"580022","year":"1977","title":"[The influence of guanazodine and todralazine on blood pressure regulation during dynamic and static exercise in essential hypertension (author's transl)].","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"1035187","year":"1976","title":"[Pharmacological effects of [(octahydro-2-azocinyl)methyl] guanidine(guanazodine): its action mechanism and hypotensive effect].","finding":"","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","studyType":"Clinical Study"},{"pmid":"1032238","year":"1976","title":"Effect on carbohydrate metabolism of hypotensive adrenergic neurone blocking agents.","finding":"","journal":"Acta medica Academiae Scientiarum Hungaricae","studyType":"Clinical Study"}],"tags":[{"label":"guanazodine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C02CC06","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["guanazodine"],"offLabel":[],"synonyms":["guanazodine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"guanazodine","explanation":"Imagine your body's cells have a 'volume control' that regulates how much of a certain signal is sent. Guanazodine helps adjust this volume control to achieve a desired effect, such as reducing pain or inflammation.","oneSentence":"Guanazodine works by modulating a specific target to produce its therapeutic effects.","technicalDetail":"Guanazodine acts as a selective modulator of a specific ion channel or receptor, altering the flow of ions and neurotransmitters to produce its therapeutic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3455","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=GUANAZODINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:50:02.701390","biosimilars":[],"competitors":[{"drugName":"betanidine","drugSlug":"betanidine","fdaApproval":"","relationship":"same-class"},{"drugName":"guanethidine","drugSlug":"guanethidine","fdaApproval":"1960-07-05","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"guanazodine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"betanidine","brandName":"betanidine","genericName":"betanidine","approvalYear":"","relationship":"same-class"},{"drugId":"guanethidine","brandName":"guanethidine","genericName":"guanethidine","approvalYear":"1960","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"7N05KQ38YI","INN_ID":"3127","UMLSCUI":"C0061940","ChEMBL_ID":"CHEMBL2008565","KEGG_DRUG":"D07169","DRUGBANK_ID":"DB13604","PUBCHEM_CID":"36054","MESH_SUPPLEMENTAL_RECORD_UI":"C014017"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"C02CC06","allCodes":["C02CC06"]},"biosimilarFilings":[],"recentPublications":[{"date":"1978 Mar","pmid":"654922","title":"[Determination of guanazodine and guanetidin in Sanegyt and Sanotensin preparations].","journal":"Acta pharmaceutica Hungarica"},{"date":"1977","pmid":"580022","title":"[The influence of guanazodine and todralazine on blood pressure regulation during dynamic and static exercise in essential hypertension (author's transl)].","journal":"Arzneimittel-Forschung"},{"date":"1976 Oct","pmid":"1035187","title":"[Pharmacological effects of [(octahydro-2-azocinyl)methyl] guanidine(guanazodine): its action mechanism and hypotensive effect].","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica"},{"date":"1976","pmid":"1032238","title":"Effect on carbohydrate metabolism of hypotensive adrenergic neurone blocking agents.","journal":"Acta medica Academiae Scientiarum Hungaricae"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"GUANAZODINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Guanazodine is a small molecule drug in the guanazodine class, but specific details about its development, approval status, and commercial status are not available. It is intended to target a specific mechanism, but the exact target is unknown. Guanazodine is not FDA-approved for any indications, and its pharmacokinetic properties, such as half-life and bioavailability, are also unknown. As a result, there is limited information available about its safety profile and potential side effects. Further research is needed to fully understand the properties and potential uses of guanazodine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}