{"id":"guanacline","rwe":[{"pmid":"3827214","year":"1987","title":"Sympathetic neuronal destruction in macaque monkeys by guanethidine and guanacline.","finding":"","journal":"Annals of neurology","studyType":"Clinical Study"},{"pmid":"3768685","year":"1986","title":"Species and structural specificity of the lipopigment accumulation and neuronal destruction induced by N-(2-guanidinoethyl)-4-methyl-1,2,5,6-tetrahydropyridine (guanacline).","finding":"","journal":"Brain research","studyType":"Clinical Study"},{"pmid":"1233209","year":"1975","title":"Persistent parotid pain due to guanacline.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"4451814","year":"1974","title":"Guanethidine and guanacline on the rat vas deferens.","finding":"","journal":"British journal of pharmacology","studyType":"Clinical Study"},{"pmid":"4851659","year":"1974","title":"Effect of long-term treatment with guanacline or guanethidine on sympathetic function.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"guanacline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cyclazenine","offLabel":[],"synonyms":["cyclazenine","guanacline","guanacline sulfate"],"timeline":[],"approvals":[],"brandName":"Cyclazenine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"guanacline","explanation":"Imagine your body's cells are like locks, and Guanacline is a key that fits into those locks. When it binds to the lock, it can either turn it on or off, or change the way it works. This can affect how different cells in the body communicate with each other and respond to signals.","oneSentence":"Guanacline is thought to work by interacting with specific receptors or enzymes in the body.","technicalDetail":"Guanacline's exact mechanism of action is unknown, but it is believed to interact with specific receptors or enzymes, potentially modulating their activity and influencing downstream signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3454","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=GUANACLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:49:59.028678","biosimilars":[],"competitors":[],"genericName":"guanacline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"2S93M1DW13","CHEBI":"CHEBI:134825","INN_ID":"2150","UMLSCUI":"C0061937","ChEMBL_ID":"CHEMBL1160385","KEGG_DRUG":"D04376","PUBCHEM_CID":"15102","SECONDARY_CAS_RN":"23389-32-4","MESH_SUPPLEMENTAL_RECORD_UI":"C004943"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1987 Jan","pmid":"3827214","title":"Sympathetic neuronal destruction in macaque monkeys by guanethidine and guanacline.","journal":"Annals of neurology"},{"date":"1986 Sep 24","pmid":"3768685","title":"Species and structural specificity of the lipopigment accumulation and neuronal destruction induced by N-(2-guanidinoethyl)-4-methyl-1,2,5,6-tetrahydropyridine (guanacline).","journal":"Brain research"},{"date":"1975 Feb 28","pmid":"1233209","title":"Persistent parotid pain due to guanacline.","journal":"European journal of clinical pharmacology"},{"date":"1974 Oct","pmid":"4451814","title":"Guanethidine and guanacline on the rat vas deferens.","journal":"British journal of pharmacology"},{"date":"1974 May","pmid":"4851659","title":"Effect of long-term treatment with guanacline or guanethidine on sympathetic function.","journal":"European journal of pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cyclazenine, also known as Guanacline, is a small molecule drug in the guanacline class. Its target and exact mechanism of action are unknown, but it is believed to work by interacting with specific receptors or enzymes in the body. Guanacline is not FDA-approved for any indications, and its commercial status, patent status, and availability of generic manufacturers are also unknown. Further research is needed to understand its potential therapeutic applications and safety profile. As a result, key safety considerations and dosing information are currently unavailable.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}