{"id":"guacetisal","rwe":[],"tags":[{"label":"guacetisal","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N02BA14","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Antitussive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Expectorants","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"guaiaspir","offLabel":[],"synonyms":["guacetisal","broncaspin","guacetisalum","guaiaspir"],"timeline":[],"approvals":[],"brandName":"Guaiaspir","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"guacetisal","explanation":"Imagine your body has a messaging system that sends signals to cause pain and inflammation. Guaiaspir blocks the production of these pain-causing messages by inhibiting the COX enzyme, which helps to reduce pain and inflammation.","oneSentence":"Guaiaspir works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins.","technicalDetail":"Guaiaspir exerts its anti-inflammatory effects by competitively inhibiting the COX-1 and COX-2 enzymes, which are involved in the synthesis of prostaglandins from arachidonic acid."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1333","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=GUACETISAL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:49:52.460258","biosimilars":[],"competitors":[{"drugName":"acetylsalicylic acid","drugSlug":"acetylsalicylic-acid","fdaApproval":"1950-04-12","relationship":"same-class"},{"drugName":"salicylamide","drugSlug":"salicylamide","fdaApproval":"","relationship":"same-class"},{"drugName":"salsalate","drugSlug":"salsalate","fdaApproval":"","relationship":"same-class"},{"drugName":"diflunisal","drugSlug":"diflunisal","fdaApproval":"1982-04-19","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"guacetisal","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetylsalicylic-acid","brandName":"acetylsalicylic acid","genericName":"acetylsalicylic acid","approvalYear":"1950","relationship":"same-class"},{"drugId":"salicylamide","brandName":"salicylamide","genericName":"salicylamide","approvalYear":"","relationship":"same-class"},{"drugId":"salsalate","brandName":"salsalate","genericName":"salsalate","approvalYear":"","relationship":"same-class"},{"drugId":"diflunisal","brandName":"diflunisal","genericName":"diflunisal","approvalYear":"1982","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"T6EKB9V2O2","CHEBI":"CHEBI:135185","INN_ID":"4512","UMLSCUI":"C0120436","ChEMBL_ID":"CHEMBL2105097","KEGG_DRUG":"D07292","DRUGBANK_ID":"DB13538","PUBCHEM_CID":"68749","MESH_SUPPLEMENTAL_RECORD_UI":"C023557"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"N02BA14","allCodes":["N02BA14"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Guaiaspir, also known as Guacetisal, is a small molecule drug in the guacetisal class. It is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Guaiaspir is used to treat various conditions, but its specific indications are unknown. The commercial status of Guaiaspir is unclear, and it may be patented or available as a generic medication. As a pharmaceutical professional, it is essential to consult the latest information on Guaiaspir's safety profile and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}