{"id":"gsk2585823-cldm-1-bpo-3-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Peeling"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis, effective against Cutibacterium acnes. Benzoyl peroxide acts as an oxidizing agent that kills bacteria and helps shed dead skin cells. The combination targets both bacterial and inflammatory components of acne pathogenesis.","oneSentence":"This combination gel delivers clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial and keratolytic agent) topically to reduce acne-causing bacteria and inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:43.144Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT01445301","phase":"PHASE3","title":"Study STF115287, a Clinical Confirmation Study of GSK2585823 in the Treatment of Acne Vulgaris in Japanese Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-09-27","conditions":"Acne Vulgaris","enrollment":800}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GSK2585823"],"phase":"phase_3","status":"active","brandName":"GSK2585823(CLDM 1%-BPO 3% gel)","genericName":"GSK2585823(CLDM 1%-BPO 3% gel)","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination gel delivers clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial and keratolytic agent) topically to reduce acne-causing bacteria and inflammation. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}