{"id":"gsk208141","safety":{"commonSideEffects":[{"rate":null,"effect":"Genital mycotic infections"},{"rate":null,"effect":"Urinary tract infections"},{"rate":null,"effect":"Polyuria"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"SGLT2 inhibitors block the reabsorption of filtered glucose in the proximal tubule of the kidney, allowing excess glucose to be excreted in the urine. This mechanism lowers blood glucose levels independently of insulin secretion and has been shown to provide cardiovascular and renal protective benefits beyond glycemic control.","oneSentence":"GSK208141 is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2) that reduces blood glucose by increasing urinary glucose excretion.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:14:42.146Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT00224484","phase":"PHASE3","title":"Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2004-04-07","conditions":"Herpes Simplex","enrollment":5960},{"nctId":"NCT00698893","phase":"PHASE1","title":"Evaluation of Safety of Candidate gD Vaccine, With or Without MPL in Healthy Herpes Simplex Virus-positive Adults","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"1992-05-01","conditions":"Herpes Simplex","enrollment":16},{"nctId":"NCT00224471","phase":"PHASE3","title":"Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2003-12","conditions":"Herpes Simplex","enrollment":671},{"nctId":"NCT00699764","phase":"PHASE3","title":"Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"1996-03","conditions":"Herpes Simplex","enrollment":2491},{"nctId":"NCT00698568","phase":"PHASE3","title":"Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"1996-10","conditions":"Prophylaxis for Herpes Simplex","enrollment":7460},{"nctId":"NCT00698490","phase":"PHASE1, PHASE2","title":"Humoral and Cellular Immune Response of Herpes Simplex (gD) Candidate Vaccines From 2 Different Cell Lines","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"1995-08","conditions":"Prophylaxis Herpes Simplex","enrollment":130},{"nctId":"NCT00697567","phase":"PHASE2","title":"Evaluation of Immunogenicity, Reactogenicity and Safety of Herpes Simplex (gD) Candidate Vaccine With/Without Adjuvant","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"1992-09","conditions":"Prophylaxis Herpes Simplex","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Herpes simplex vaccine","gD2-AS04 vaccine"],"phase":"phase_3","status":"active","brandName":"GSK208141","genericName":"GSK208141","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"GSK208141 is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2) that reduces blood glucose by increasing urinary glucose excretion. Used for Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}